Activated point mutants of FGFR2 (Q45314368)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2033519)

Language	Label	Description	Also known as
English	Activated point mutants of FGFR2	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-2033519)

Statements

instance of

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8 July 2022

FGFR2 mutant receptor activation

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-2033519

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8 July 2022

Dimerization of FGFR2 ligand-independent mutants

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8 July 2022

Autocatalytic phosphorylation of FGFR2 ligand-independent mutants

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8 July 2022

FGFR2b mutants bind an expanded range of ligands

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8 July 2022

Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding

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8 July 2022

FGFR2c mutants bind an expanded range of ligands

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8 July 2022

Dimerization of FGFR2 point mutants with enhanced kinase activity

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8 July 2022

Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding

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8 July 2022

FP-1039 acts as a ligand-trap for FGFR2b-binding ligands in endometrial cancer

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8 July 2022

Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity

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8 July 2022

Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors

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8 July 2022

Drug-sensitive FGFR2 mutations in endometrial carcinoma

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8 July 2022

Fibroblast growth factor receptor 2 mutations in Beare-Stevenson cutis gyrata syndrome

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8 July 2022

FGFR2 mutations are rare across histologic subtypes of ovarian cancer

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8 July 2022

Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers

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8 July 2022

Syndromic craniosynostosis: from history to hydrogen bonds

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8 July 2022

A common mutation in the fibroblast growth factor receptor 1 gene in Pfeiffer syndrome

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8 July 2022

FGFR activation in skeletal disorders: too much of a good thing

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8 July 2022

Fibroblast growth factor receptors: lessons from the genes

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8 July 2022

Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain

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8 July 2022

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome

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8 July 2022

A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases

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8 July 2022

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities

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8 July 2022

Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

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8 July 2022

Inhibition of activated fibroblast growth factor receptor 2 in endometrial cancer cells induces cell death despite PTEN abrogation

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8 July 2022

Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.

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8 July 2022

Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes

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8 July 2022

Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3.

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8 July 2022

Identifiers

1 reference

8 July 2022

Activated point mutants of FGFR2 (Q45314368)

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Activated point mutants of FGFR2 (Q45314368)

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Identifiers

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Wikinews(0 entries)

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