TP53 Regulates Transcription of DNA Repair Genes (Q45316782)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6796648)

Language	Label	Description	Also known as
English	TP53 Regulates Transcription of DNA Repair Genes	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6796648)

Statements

instance of

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8 July 2022

Transcriptional Regulation by TP53

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-6796648

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8 July 2022

TP53 and AP-1 bind the MSH2 promoter

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8 July 2022

TP53 and AP-1 stimulate MSH2 expression

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8 July 2022

TP53 stimulates PMS2 expression

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8 July 2022

TP53 binds the PMS2 gene

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8 July 2022

TP53 binds the MLH1 gene

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8 July 2022

TP53 stimulates MLH1 expression

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8 July 2022

TP53 binds the FANCC gene

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8 July 2022

TP53 binds the CCNK gene

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8 July 2022

TP53 binds the DDB2 gene

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8 July 2022

TP53 stimulates DDB2 expression

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8 July 2022

TP53 stimulates FANCC expression

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8 July 2022

TP53 stimulates CCNK expression

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8 July 2022

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8 July 2022

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8 July 2022

CCNK:CDK12 binds RNA Pol II at DNA repair genes

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8 July 2022

CDK12 phosphorylates RNA Pol II CTD at DNA repair genes

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8 July 2022

CDK12 stimulates expression of DNA repair genes

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8 July 2022

Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

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8 July 2022

The structure and substrate specificity of human Cdk12/Cyclin K

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8 July 2022

p53 and c-Jun functionally synergize in the regulation of the DNA repair gene hMSH2 in response to UV.

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8 July 2022

Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.

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8 July 2022

The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes

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8 July 2022

p53 responsive nucleotide excision repair gene products p48 and XPC, but not p53, localize to sites of UV-irradiation-induced DNA damage, in vivo

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8 July 2022

p53 activates Fanconi anemia group C gene expression

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8 July 2022

Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex

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8 July 2022

Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex

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8 July 2022

RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence

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8 July 2022

Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II

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8 July 2022

p53-mediated regulation of proliferating cell nuclear antigen expression in cells exposed to ionizing radiation

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8 July 2022

p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice.

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8 July 2022

Cyclin K as a direct transcriptional target of the p53 tumor suppressor

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8 July 2022

A nucleotide excision repair master-switch: p53 regulated coordinate induction of global genomic repair genes

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8 July 2022

p53 coordinates base excision repair to prevent genomic instability

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8 July 2022

Functional evolution of the p53 regulatory network through its target response elements

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8 July 2022

Identification of a p53 response element in the promoter region of the hMSH2 gene required for expression in A2780 ovarian cancer cells

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8 July 2022

Identifiers

1 reference

8 July 2022

TP53 Regulates Transcription of DNA Repair Genes (Q45316782)

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TP53 Regulates Transcription of DNA Repair Genes (Q45316782)

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