MET Receptor Activation (Q45318114)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6806942)

Language	Label	Description	Also known as
English	MET Receptor Activation	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6806942)

Statements

instance of

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8 July 2022

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-6806942

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8 July 2022

HPN heterodimer cleaves pro-HGF to form HGF dimer

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HGFAC cleaves pro-HGF to form HGF dimer

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MET receptor dimerizes

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8 July 2022

MET dimers autophosphorylate

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8 July 2022

Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase

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8 July 2022

Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2.

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8 July 2022

CD44-independent activation of the Met signaling pathway by HGF and InlB.

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8 July 2022

Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling

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8 July 2022

Autophosphorylation modulates the kinase activity and oncogenic potential of the Met receptor tyrosine kinase

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8 July 2022

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA.

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8 July 2022

Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model

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8 July 2022

Tyrosines1234-1235 are critical for activation of the tyrosine kinase encoded by the MET proto-oncogene (HGF receptor).

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8 July 2022

Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor

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8 July 2022

Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

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8 July 2022

c-Met recruits ICAM-1 as a coreceptor to compensate for the loss of CD44 in Cd44 null mice

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8 July 2022

CD44 is required for two consecutive steps in HGF/c-Met signaling.

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8 July 2022

A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family

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8 July 2022

Internalization of Met requires the co-receptor CD44v6 and its link to ERM proteins.

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8 July 2022

Structural basis of hepatocyte growth factor/scatter factor and MET signalling

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8 July 2022

Oligomerization-dependent changes in the thermodynamic properties of the TPR-MET receptor tyrosine kinase

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8 July 2022

Identifiers

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8 July 2022

MET Receptor Activation (Q45318114)

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MET Receptor Activation (Q45318114)

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