PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Q45318297)

An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6811558)

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English	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	An instance of the biological pathway in Homo sapiens with Reactome ID (R-HSA-6811558)

Statements

instance of

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8 July 2022

regulation of phosphatidylinositol 3-kinase signaling

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8 July 2022

Negative regulation of the PI3K/AKT network

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8 July 2022

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8 July 2022

https://identifiers.org/reactome:R-HSA-6811558

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PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

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PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane

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AKT1 dephosphorylation by PP2A-B56-beta,gamma

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Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307

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IER3 recruits MAPKs to PP2A-B56-beta,gamma

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MAPKs phosphorylate PP2A

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PI3K phosphorylates PIP2 to PIP3

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Regulation and cellular roles of phosphoinositide 5-kinases

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Localization, regulation and function of type II phosphatidylinositol 5-phosphate 4-kinases

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Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

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8 July 2022

A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate

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Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

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8 July 2022

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

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8 July 2022

A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis

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8 July 2022

Phospholipase D signaling: orchestration by PIP2 and small GTPases

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The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site

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Localization of phosphatidylinositol phosphate kinase IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron

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B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

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8 July 2022

Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

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8 July 2022

Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

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8 July 2022

Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity

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8 July 2022

PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.

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8 July 2022

Identifiers

1 reference

8 July 2022

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Q45318297)

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PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Q45318297)

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