Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation (Q45342642)

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scientific article published on 14 February 2013

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English	Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation	scientific article published on 14 February 2013

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation (English)

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

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inflammasome complex

1 reference

based on heuristic

inferred from title

author name string

Jian-Quan Shi

1

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Chu-Chu Zhang

2

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Xiu-Lan Sun

3

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Xin-Xin Cheng

4

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Jiang-Bo Wang

5

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Ying-Dong Zhang

6

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Jun Xu

7

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

Hai-Qiang Zou

8

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Europe PubMed Central

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1 July 2019

http://europepmc.org/abstract/PMC/6493386

publication date

14 February 2013

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

CNS Neuroscience & Therapeutics

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

19

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PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

4

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

262-268

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Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6493386/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1111%2FCNS.12066

21 January 2018

Amyloid precursor protein processing and Alzheimer's disease

1 reference

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Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature

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Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice

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MyD88 deficiency ameliorates β-amyloidosis in an animal model of Alzheimer's disease

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Inflammation and NF-kappaB in Alzheimer's disease and diabetes.

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Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides

1 reference

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Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

1 reference

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Inhibition of Abeta production by NF-kappaB inhibitors

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

1 reference

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21 January 2018

The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

1 reference

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21 January 2018

Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

1 reference

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21 January 2018

Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug

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Artemisinin, an anti-malarial agent, inhibits rat cardiac hypertrophy via inhibition of NF-κB signaling

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The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

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Artemisinin attenuates lipopolysaccharide-stimulated proinflammatory responses by inhibiting NF-κB pathway in microglia cells

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Therapeutic effect of artemisinin on lupus nephritis mice and its mechanisms

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Anti-inflammatory properties and regulatory mechanism of a novel derivative of artemisinin in experimental autoimmune encephalomyelitis

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

1 reference

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21 January 2018

Utilization of APPswe/PS1dE9 Transgenic Mice in Research of Alzheimer's Disease: Focus on Gene Therapy and Cell-Based Therapy Applications

1 reference

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21 January 2018

Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease

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Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver

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Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models

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21 January 2018

The antimalarial drug artemisinin alkylates heme in infected mice

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Relationship between inflammatory mediators, Aβ levels and ApoE genotype in Alzheimer disease

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Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study

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21 January 2018

Activation of nuclear factor-kappa B by beta-amyloid peptides and interferon-gamma in murine microglia

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21 January 2018

Amyloid beta-peptide activates nuclear factor-kappaB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells.

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Sphingosylphosphorylcholine attenuated β-amyloid production by reducing BACE1 expression and catalysis in PC12 cells.

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Anatabine lowers Alzheimer's Aβ production in vitro and in vivo.

1 reference

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Obovatol attenuates LPS-induced memory impairments in mice via inhibition of NF-κB signaling pathway.

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21 January 2018

Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

1 reference

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21 January 2018

Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations

1 reference

https://api.crossref.org/works/10.1111%2FCNS.12066

21 January 2018

PPARγ agonist pioglitazone reverses memory impairment and biochemical changes in a mouse model of type 2 diabetes mellitus.

1 reference

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21 January 2018

Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FCNS.12066

21 January 2018

NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

1 reference

https://api.crossref.org/works/10.1111%2FCNS.12066

21 January 2018

Decreased clearance of CNS beta-amyloid in Alzheimer's disease

1 reference

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21 January 2018

Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease

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21 January 2018

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

1 reference

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21 January 2018

Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid

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21 January 2018

Nonsteroidal Antiinflammatory Drugs and the Risk of Alzheimer's Disease

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21 January 2018

RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406388

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Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406388

12 December 2020

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inferred from PubMed ID database lookup

Obovatol improves cognitive functions in animal models for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Artemisinin attenuates post-infarct myocardial remodeling by down-regulating the NF-κB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/23406388

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/CNS.12066

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

1 July 2019

http://europepmc.org/abstract/PMC/6493386

ResearchGate publication ID

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