Impact of high-throughput screening in biomedical research (Q45352809)

13 December 2017

1 reference

title

Impact of high-throughput screening in biomedical research (English)

1 reference

13 December 2017

Dragan A Cirovic

5

0 references

author name string

Ricardo Macarron

1

1 reference

13 December 2017

Martyn N Banks

2

1 reference

13 December 2017

Dejan Bojanic

3

1 reference

13 December 2017

David J Burns

4

1 reference

13 December 2017

Tina Garyantes

6

1 reference

13 December 2017

Darren V S Green

7

1 reference

13 December 2017

Robert P Hertzberg

8

1 reference

13 December 2017

William P Janzen

9

1 reference

13 December 2017

Jeff W Paslay

10

1 reference

13 December 2017

Ulrich Schopfer

11

1 reference

13 December 2017

G Sitta Sittampalam

12

1 reference

13 December 2017

1 March 2011

1 reference

Nature Reviews Drug Discovery

13 December 2017

1 reference

13 December 2017

10

1 reference

13 December 2017

3

1 reference

13 December 2017

188-195

1 reference

https://scigraph.springernature.com/pub.10.1038/nrd3368

13 December 2017

0 references

cites work

The Year's New Drugs & Biologics - 2009.

1 reference

Drug repositioning: identifying and developing new uses for existing drugs

21 January 2018

1 reference

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

21 January 2018

1 reference

An efficient method for the detection and elimination of systematic error in high-throughput screening.

21 January 2018

1 reference

Process validation and screen reproducibility in high-throughput screening.

21 January 2018

1 reference

A standard operating procedure for assessing liquid handler performance in high-throughput screening.

21 January 2018

1 reference

High-throughput screening: update on practices and success

21 January 2018

1 reference

Hit and lead generation: beyond high-throughput screening

21 January 2018

1 reference

Can the pharmaceutical industry reduce attrition rates?

21 January 2018

1 reference

An analysis of the binding efficiencies of drugs and their leads in successful drug discovery programs

21 January 2018

1 reference

Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity

21 January 2018

1 reference

Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis

21 January 2018

1 reference

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 1. Discovery and optimization of salicylaldehyde thiosemicarbazone thrombopoietin mimics.

21 January 2018

1 reference

Identification of a pharmacophore for thrombopoietic activity of small, non-peptidyl molecules. 2. Rational design of naphtho[1,2-d]imidazole thrombopoietin mimics

21 January 2018

1 reference

Discovery and characterization of a selective, nonpeptidyl thrombopoietin receptor agonist.

21 January 2018

1 reference

Drug discovery in jeopardy

21 January 2018

1 reference

Identification of Hepatitis C Virus NS5A Inhibitors

21 January 2018

1 reference

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

21 January 2018

1 reference

Is there a difference between leads and drugs? A historical perspective

21 January 2018

1 reference

Pursuing the leadlikeness concept in pharmaceutical research.

21 January 2018

1 reference

Key aspects of the Novartis compound collection enhancement project for the compilation of a comprehensive chemogenomics drug discovery screening collection

21 January 2018

1 reference

Defining and maintaining a high quality screening collection: the GSK experience

21 January 2018

1 reference

Enhancements of screening collections to address areas of unmet medical need: an industry perspective

21 January 2018

1 reference

21 January 2018

1 reference

Design of a compound screening collection for use in high throughput screening

21 January 2018

1 reference

Do structurally similar molecules have similar biological activity?

21 January 2018

1 reference

Lessons from 60 years of pharmaceutical innovation

21 January 2018

1 reference

The completed human genome: implications for chemical biology

21 January 2018

1 reference

Driving drug discovery: the fundamental role of academic labs.

21 January 2018

1 reference

The art of the chemical probe

21 January 2018

1 reference

Case study: impact of technology investment on lead discovery at Bristol-Myers Squibb, 1998-2006.

21 January 2018

1 reference

Application of division arrest technology to cell-based HTS: comparison with frozen and fresh cells

21 January 2018

1 reference

Evaluation of division-arrested cells for cell-based high-throughput screening and profiling

21 January 2018

1 reference

Evolution of cell-based reagent provision

21 January 2018

1 reference

Cryopreserved cells facilitate cell-based drug discovery

21 January 2018

1 reference

G-protein-coupled receptors in drug discovery: nanosizing using cell-free technologies and molecular biology approaches.

21 January 2018

1 reference

Confocal fluorescence microscopy for high-throughput screening of G-protein coupled receptors.

21 January 2018

1 reference

Fluorescence techniques: shedding light on ligand-receptor interactions

21 January 2018

1 reference

Current in vitro kinase assay technologies: the quest for a universal format

21 January 2018

1 reference

High-content analysis of kinase activity in cells

21 January 2018

1 reference

The A, B, Cs of G-protein-coupled receptor pharmacology in assay development for HTS.

21 January 2018

1 reference

G-protein coupled receptor assays: to measure affinity or efficacy that is the question

21 January 2018

1 reference

Functional cell-based assays in microliter volumes for ultra-high throughput screening

21 January 2018

1 reference

Cellular assays as portals to seven-transmembrane receptor-based drug discovery

21 January 2018

1 reference

A specific inhibitor of the epidermal growth factor receptor tyrosine kinase

21 January 2018

1 reference

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer.

21 January 2018

1 reference

Structure-based design of HIV protease inhibitors: 4-hydroxycoumarins and 4-hydroxy-2-pyrones as non-peptidic inhibitors

21 January 2018

1 reference

Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

21 January 2018

1 reference

2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (d

21 January 2018

1 reference

Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists

21 January 2018

1 reference

From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase

21 January 2018

1 reference

Who wants to be irrational?

21 January 2018

1 reference

How to improve R&D productivity: the pharmaceutical industry's grand challenge

31 March 2020

1 reference

The influence of lead discovery strategies on the properties of drug candidates

31 March 2020

1 reference

Molecular biology. Industrial-style screening meets academic biology

31 March 2020

1 reference

OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor Antagonist

31 March 2020

1 reference

Rebuilding the R&D engine in big pharma.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21358738

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Overcoming the obstacles in the pharma/biotech industry: 2009 update

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21358738

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3368

1 reference

Dimensions Publication ID

13 December 2017

0 references

1 reference