Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice (Q45401428)

14 December 2017

Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice (English)

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14 December 2017

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arterial hypertension

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Nicholas W Morrell

8

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Loredana Ciuclan

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object named as

Loredana Ciuclan

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14 December 2017

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Gabor Jarai

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Nicholas Duggan

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Kellyann Sheppard

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Liqun Dong

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Daniel Sutton

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Martin Hussey

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Jenny Simmons

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Matthew Edwards

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Gerald Dubois

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Matthew Thomas

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Gino Van Heeke

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14 December 2017

Karen England

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language of work or name

English

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publication date

1 November 2013

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The American Journal of Pathology

14 December 2017

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183

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5

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1461-1473

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describes a project that uses

14 December 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5691347/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Gremlin plays a key role in the pathogenesis of pulmonary hypertension

24 May 2018

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BMP type II receptor deficiency confers resistance to growth inhibition by TGF-β in pulmonary artery smooth muscle cells: role of proinflammatory cytokines

24 May 2018

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Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins

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The Effects of Antiangiogenic Compound SU5416 in a Rat Model of Pulmonary Arterial Hypertension

24 May 2018

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A novel BMPR2 gene mutation associated with exercise-induced pulmonary hypertension in septal defects

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Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs

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In vivo delivery of Gremlin siRNA plasmid reveals therapeutic potential against diabetic nephropathy by recovering bone morphogenetic protein-7.

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Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

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BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertension

24 May 2018

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Role of gremlin in the lung: development and disease

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Cellular and molecular basis of pulmonary arterial hypertension

24 May 2018

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Bone morphogenetic protein 4 inhibits TGF-beta2 stimulation of extracellular matrix proteins in optic nerve head cells: role of gremlin in ECM modulation

24 May 2018

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Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance

24 May 2018

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Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage

24 May 2018

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Pathobiology of pulmonary hypertension

24 May 2018

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Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis

24 May 2018

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24 May 2018

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24 May 2018

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A novel murine model of severe pulmonary arterial hypertension

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Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

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Altered bone morphogenetic protein and transforming growth factor-beta signaling in rat models of pulmonary hypertension: potential for activin receptor-like kinase-5 inhibition in prevention and progression of disease

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Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by mo

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Investigation of Second Genetic Hits at the BMPR2 Locus as a Modulator of Disease Progression in Familial Pulmonary Arterial Hypertension

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Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension

1 December 2018

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Suppression of type II bone morphogenic protein receptor in vascular smooth muscle induces pulmonary arterial hypertension in transgenic mice

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Dysregulated Bone Morphogenetic Protein Signaling in Monocrotaline-Induced Pulmonary Arterial Hypertension

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Clinical implications of determining BMPR2 mutation status in a large cohort of children and adults with pulmonary arterial hypertension

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Formation of plexiform lesions in experimental severe pulmonary arterial hypertension

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Identifiers

DOI

1 reference

14 December 2017

1 reference

14 December 2017

PubMed publication ID

24160323

1 reference