Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene (Q45530812)

14 December 2017

Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene (English)

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respiratory syncytial virus

14 December 2017

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pharmacology

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author name string

Weidong Zhang

1

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14 December 2017

Hong Yang

2

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14 December 2017

Xiaoyuan Kong

3

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14 December 2017

Subhra Mohapatra

4

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14 December 2017

Homero San Juan-Vergara

5

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14 December 2017

Gary Hellermann

6

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14 December 2017

Sumita Behera

7

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14 December 2017

Rajeswari Singam

8

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14 December 2017

Richard F Lockey

9

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14 December 2017

Shyam S Mohapatra

10

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14 December 2017

language of work or name

English

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publication date

26 December 2004

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14 December 2017

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14 December 2017

11

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14 December 2017

56-62

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14 December 2017

1

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https://scigraph.springernature.com/pub.10.1038/nm1174

14 December 2017

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cites work

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Basic epidemiology and immunopathology of RSV in children.

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Recombinant respiratory syncytial viruses with deletions in the NS1, NS2, SH, and M2-2 genes are attenuated in vitro and in vivo

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Recombinant respiratory syncytial virus that does not express the NS1 or M2-2 protein is highly attenuated and immunogenic in chimpanzees

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Immunity to and frequency of reinfection with respiratory syncytial virus

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Respiratory syncytial virus infection in infants is associated with predominant Th-2-like response

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Recurrent respiratory syncytial virus infections in allergen-sensitized mice lead to persistent airway inflammation and hyperresponsiveness

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Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling

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Intranasal IFN-gamma gene transfer protects BALB/c mice against respiratory syncytial virus infection

21 January 2018

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Intranasal gene transfer by chitosan-DNA nanospheres protects BALB/c mice against acute respiratory syncytial virus infection

21 January 2018

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Mucosal gene expression vaccine: a novel vaccine strategy for respiratory syncytial virus

21 January 2018

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Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells

21 January 2018

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Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3

21 January 2018

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Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response

21 January 2018

1 reference

Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]

21 January 2018

1 reference

RNA-triggered gene silencing

21 January 2018

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Iduronic acid-containing glycosaminoglycans on target cells are required for efficient respiratory syncytial virus infection

21 January 2018

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Transcriptional and posttranscriptional regulation of exogenous human beta interferon gene in simian cells defective in interferon synthesis

21 January 2018

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Targeted therapy of respiratory syncytial virus in African green monkeys by intranasally administered 2-5A antisense

21 January 2018

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Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines.

21 January 2018

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How cells respond to interferons

21 January 2018

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On the role of IRF in host defense

21 January 2018

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21 January 2018

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Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either

21 January 2018

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Activation of the interferon system by short-interfering RNAs

21 January 2018

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Determinants of interferon-stimulated gene induction by RNAi vectors

21 January 2018

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Monocyte interleukin-12 production is inversely related to duration of respiratory failure in respiratory syncytial virus bronchiolitis

21 January 2018

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Respiratory syncytial virus decreases the capacity of myeloid dendritic cells to induce interferon-gamma in naïve T cells

21 January 2018

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Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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Childhood asthma following hospitalization with acute viral bronchiolitis in infancy

21 January 2018

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7 January 2021

Review of epidemiology and clinical risk factors for severe respiratory syncytial virus (RSV) infection

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7 January 2021

Altered growth characteristics of recombinant respiratory syncytial viruses which do not produce NS2 protein

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7 January 2021

Chitosan IFN-gamma-pDNA Nanoparticle (CIN) Therapy for Allergic Asthma

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7 January 2021

Genetic therapy: on the brink of a new future

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7 January 2021

Attenuation of dengue virus infection by adeno-associated virus-mediated siRNA delivery

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7 January 2021

Intracellular disposition and metabolism of fluorescently-labeled unmodified and modified oligonucleotides microinjected into mammalian cells

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7 January 2021

The NS1 protein of human respiratory syncytial virus is a potent inhibitor of minigenome transcription and RNA replication

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7 January 2021

Immunostimulatory DNA sequences necessary for effective intradermal gene immunization

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7 January 2021

Identifiers

DOI

10.1038/NM1174

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Dimensions Publication ID

14 December 2017

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