High attenuation and immunogenicity of a simian immunodeficiency virus expressing a proteolysis-resistant inhibitor of NF-kappaB. (Q45710556)

15 December 2017

title

High attenuation and immunogenicity of a simian immunodeficiency virus expressing a proteolysis-resistant inhibitor of NF-kappaB. (English)

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Simian immunodeficiency virus

15 December 2017

main subject

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7

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6

Mark G Lewis

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10

Joseph Adelsberger

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Ileana Quinto

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Antimina Puca

2

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Jack Greenhouse

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Peter Silvera

4

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Jake Yalley-Ogunro

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Francesca Trimboli

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Russ Byrum

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David Venzon

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Xueni Chen

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Giuseppe Scala

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15 December 2017

language of work or name

English

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publication date

30 October 2003

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Journal of Biological Chemistry

15 December 2017

published in

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15 December 2017

volume

279

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issue

3

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15 December 2017

page(s)

1720-1728

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Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene

15 December 2017

cites work

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques

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Pathogenic conversion of live attenuated simian immunodeficiency virus vaccines is associated with expression of truncated Nef

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Construction and in vitro properties of a series of attenuated simian immunodeficiency viruses with all accessory genes deleted

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Novel, live attenuated simian immunodeficiency virus constructs containing major deletions in leader RNA sequences

21 January 2018

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A role for carbohydrates in immune evasion in AIDS.

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Quintuple deglycosylation mutant of simian immunodeficiency virus SIVmac239 in rhesus macaques: robust primary replication, tightly contained chronic infection, and elicitation of potent immunity against the parental wild-type strain

21 January 2018

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Multifaceted activities of the HIV-1 transactivator of transcription, Tat.

21 January 2018

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An inducible transcription factor activates expression of human immunodeficiency virus in T cells

21 January 2018

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An NF-kappaB site in the 5'-untranslated leader region of the human immunodeficiency virus type 1 enhances the viral expression in response to NF-kappaB-activating stimuli.

21 January 2018

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Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development

21 January 2018

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Simian immunodeficiency virus in which nef and U3 sequences do not overlap replicates efficiently in vitro and in vivo in rhesus macaques

21 January 2018

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Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

21 January 2018

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Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes

21 January 2018

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Analysis of Gag-specific cytotoxic T lymphocytes in simian immunodeficiency virus-infected rhesus monkeys by cell staining with a tetrameric major histocompatibility complex class I-peptide complex

21 January 2018

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Simian immunodeficiency virus-specific cytotoxic T lymphocytes and protection against challenge in rhesus macaques immunized with a live attenuated simian immunodeficiency virus vaccine.

21 January 2018

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Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism

21 January 2018

1 reference

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Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.

21 January 2018

1 reference

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Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells

21 January 2018

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Frequency and function of HIV-specific CD8(+) T cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M309375200

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15 December 2017

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