The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins (Q45722305)

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scientific article published in August 2003

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English	The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins	scientific article published in August 2003

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

The herpes simplex virus (HSV) protein ICP34.5 is a virion component that forms a DNA-binding complex with proliferating cell nuclear antigen and HSV replication proteins (English)

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

1 reference

based on heuristic

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author name string

June Harland

1

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

Paul Dunn

2

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

Euan Cameron

3

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

Joe Conner

4

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

S Moira Brown

5

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Europe PubMed Central

PubMed publication ID

15 December 2017

publication date

1 August 2003

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Europe PubMed Central

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15 December 2017

Journal of NeuroVirology

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Europe PubMed Central

PubMed publication ID

15 December 2017

9

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Europe PubMed Central

PubMed publication ID

15 December 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

477-488

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of experimental subcutaneous human melanoma with a replication-restricted herpes simplex virus mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the herpes simplex virus type 1 strain 17+ neurovirulence gene RL1 and its expression in a bacterial system

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Monoclonal antibodies against herpes simplex virus type 1-infected nuclei defining and localizing the ICP8 protein, 65K DNA-binding protein and polypeptides of the ICP35 family

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histopathological responses in the CNS following inoculation with a non-neurovirulent mutant (1716) of herpes simplex virus type 1 (HSV 1): relevance for gene and cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of the herpes simplex virus type 1 65-kilodalton DNA-binding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurovirulence factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The herpes simplex virus type 1 strain 17 open reading frame RL1 encodes a polypeptide of apparent M(r) 37K equivalent to ICP34.5 of herpes simplex virus type 1 strain F.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MyD genes in negative growth control.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the proliferating cell nuclear antigen (PCNA) in DNA repair induced by alkylating agents and oxidative damage in human fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin (PCNA, auxiliary protein of DNA polymerase delta) is a central component of the pathway(s) leading to DNA replication and cell division

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intralesional injection of herpes simplex virus 1716 in metastatic melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of Experimental Intracranial Murine Melanoma with a Neuroattenuated Herpes Simplex Virus 1 Mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PCNA: structure, functions and interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin: a nuclear protein whose level correlates directly with the proliferative state of normal as well as transformed cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herpes simplex 1716--an ICP 34.5 mutant--is severely replication restricted in human skin xenografts in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mapping of epitopes on the 65k DNA-binding protein of herpes simplex virus type 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structures of herpes simplex virus type 1 genes required for replication of virus DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic studies with herpes simplex virus type 1. The isolation of temperature-sensitive mutants, their arrangement into complementation groups and recombination analysis leading to a linkage map.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of DNA loop supercoiling and organization in cells infected by herpes simplex virus type 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of her

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A method for identifying the viral genes required for herpesvirus DNA replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell type and cell state determine differential in vitro growth of non-neurovirulent ICP34.5-negative herpes simplex virus types 1 and 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a "replication-restricted" herpes virus to treat experimental human malignant mesothelioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector--potential glioblastoma targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of replication factor C from Saccharomyces cerevisiae: a component of the leading-strand DNA replication complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The 65,000-Mr DNA-binding and virion trans-inducing proteins of herpes simplex virus type 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Who binds wins: Competition for PCNA rings out cell-cycle changes

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early induction of DNA single-stranded breaks in cells infected by herpes simplex virus type 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific phenotypic restoration of an attenuated virus by knockout of a host resistance gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The range and distribution of murine central nervous system cells infected with the gamma(1)34.5- mutant of herpes simplex virus 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PREPs: herpes simplex virus type 1-specific particles produced by infected cells when viral DNA replication is blocked

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A herpes simplex virus type 1 gamma34.5 second-site suppressor mutant that exhibits enhanced growth in cultured glioblastoma cells is severely attenuated in animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proliferating cell nuclear antigen is required for DNA excision repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The herpes simplex virus virulence factor ICP34.5 and the cellular protein MyD116 complex with proliferating cell nuclear antigen through the 63-amino-acid domain conserved in ICP34.5, MyD116, and GADD34.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral replication and latency reactivation kinetics of the non-neurovirulent herpes simplex virus type 1 variant 1716

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Therapy of a murine model of pediatric brain tumors using a herpes simplex virus type-1 ICP34.5 mutant and demonstration of viral replication within the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and function in the herpes simplex virus 1 RNA-binding protein U(s)11: mapping of the domain required for ribosomal and nucleolar association and RNA binding in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The products of gene US11 of herpes simplex virus type 1 are DNA-binding and localize to the nucleoli of infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in the nuclear distribution of cyclin (PCNA) during S-phase are not triggered by post-translational modifications that are expected to moderately affect its charge

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The herpes simplex virus type 1 UL8 protein influences the intracellular localization of the UL52 but not the ICP8 or POL replication proteins in virus-infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants that retain susceptibility to acyclovir

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12907392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1080/13550280390218788

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

15 December 2017

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