The effects of interferon-alpha and acyclovir on herpes simplex virus type-1 ribonucleotide reductase (Q45754235)

15 December 2017

title

The effects of interferon-alpha and acyclovir on herpes simplex virus type-1 ribonucleotide reductase (English)

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15 December 2017

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W J O'Brien

1

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15 December 2017

J Narasimhan

2

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15 December 2017

J Guy

3

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15 December 2017

P Tom

4

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15 December 2017

J L Taylor

5

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15 December 2017

publication date

1 May 1998

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15 December 2017

published in

Antiviral Research

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15 December 2017

volume

38

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15 December 2017

issue

2

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15 December 2017

page(s)

107-116

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15 December 2017

Detailed characterization of the mRNA mapping in the HindIII fragment K region of the herpes simplex virus type 1 genome

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Identification and separation of the two subunits of the herpes simplex virus ribonucleotide reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

The herpes simplex virus ribonucleotide reductase is required for ocular virulence

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Ribonucleotide reductase encoded by herpes simplex virus is a determinant of the pathogenicity of the virus in mice and a valid antiviral target

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of her

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Herpes simplex virus ribonucleotide reductase mutants are hypersensitive to acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Specific inhibition of herpesvirus ribonucleotide reductase by a nonapeptide derived from the carboxy terminus of subunit 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Intracellular localisation of herpes simplex virus type 1 ribonucleotide reductase subunits during infection of cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Specific inhibition of herpesvirus ribonucleotide reductase by synthetic peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl) guanine

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

The ribonucleotide reductase induced by herpes simplex virus type 1 involves minimally a complex of two polypeptides (136K and 38K).

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Effect of acyclovir on the deoxyribonucleoside triphosphate pool levels in Vero cells infected with herpes simplex virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Cloning of herpes simplex virus type 1 sequences representing the whole genome

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Factor(s) present in herpes simplex virus type 1-infected cells can compensate for the loss of the large subunit of the viral ribonucleotide reductase: characterization of an ICP6 deletion mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Herpes simplex virus type 1-induced ribonucleotide reductase activity is dispensable for virus growth and DNA synthesis: isolation and characterization of an ICP6 lacZ insertion mutant

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Combined effects of acyclovir and human interferon-alpha on herpes simplex virus replication in cultured neural cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Delection of the herpes simplex virus type 1 ribonucleotide reductase gene alters virulence and latency in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

The herpes simplex virus type 1 ribonucleotide reductase is a tight complex of the type alpha 2 beta 2 composed of 40K and 140K proteins, of which the latter shows multiple forms due to proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

A herpes simplex virus ribonucleotide reductase deletion mutant is defective for productive acute and reactivatable latent infections of mice and for replication in mouse cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Combined interaction of antiherpes substances and interferon ? on the multiplication of herpes simplex virus

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Effects of ribonucleotide reductase inhibition on pyrimidine deoxynucleotide metabolism in acyclovir-treated cells infected with herpes simplex virus type 1

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Use of human monocytes in the evaluation of antiviral drugs: quantitation of HSV-1 cytopathic effects

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

A potent peptidomimetic inhibitor of HSV ribonucleotide reductase with antiviral activity in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Synergistic topical therapy by acyclovir and A1110U for herpes simplex virus induced zosteriform rash in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Oligopeptides inhibit the ribonucleotide reductase of herpes simplex virus by causing subunit separation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Organization of the Herpes Simplex Virus Type 1 Transcription Unit Encoding Two Early Proteins with Molecular Weights of 140000 and 40000

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Interferon treatment inhibits onset of herpes simplex virus immediate-early transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Inhibition of herpes simplex virus type 1 ribonucleotide reductase by substituted tetrapeptide derivatives.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Nucleoside metabolism in herpes simplex virus-infected cells following treatment with interferon and acyclovir, a possible mechanism of synergistic antiviral activity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Effect of interferon-alpha on the steady-state levels of thymine, thymidine, guanine, and guanosine metabolites in herpes simplex virus-type 1-infected cells

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Herpes simplex virus type 1 ribonucleotide reductase: selective and synergistic inactivation by A1110U and its iron complex

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Ribonucleotide reductase: an important enzyme in the replication of herpes simplex virus type 1 and a target for antiviral chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Regulation of deoxyribotide synthesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

From RNA to DNA, why so many ribonucleotide reductases?

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Topical treatment of infection with acyclovir-resistant mucocutaneous herpes simplex virus with the ribonucleotide reductase inhibitor 348U87 in combination with acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Thiosemicarbazones of 2-acetylpyridine, 2-acetylquinoline, 1-acetylisoquinoline, and related compounds as inhibitors of herpes simplex virus in vitro and in a cutaneous herpes guinea pig model

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Identification of the stable free radical tyrosine residue in ribonucleotide reductase. A sequence comparison.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Inhibition of ribonucleotide reductases encoded by herpes simplex viruses

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Potentiation of antiherpetic activity of acyclovir by ribonucleotide reductase inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

2-Acetylpyridine 5-[(dimethylamino)thiocarbonyl]-thiocarbonohydrazone (A1110U), a potent inactivator of ribonucleotide reductases of herpes simplex and varicella-zoster viruses and a potentiator of acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Herpes and human ribonucleotide reductases. Inhibition by 2-acetylpyridine 5-[(2-chloroanilino)-thiocarbonyl]-thiocarbonohydrazone (348U87).

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Inactivators of herpes simplex virus ribonucleotide reductase: hematological profiles and in vivo potentiation of the antiviral activity of acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Combined anti-herpes virus activity of nucleoside analogs and interferon

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Combined effects of interferon-alpha and acyclovir on herpes simplex virus type 1 DNA polymerase and alkaline DNase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Selective inhibition of herpes simplex virus ribonucleoside diphosphate reductase by derivatives of 2-acetylpyridine thiosemicarbazone

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Structure-activity relationships among alpha-(N)-heterocyclic acyl thiosemicarbazones and related compounds as inhibitors of herpes simplex virus type 1-specified ribonucleoside diphosphate reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

Herpes simplex virus type 1 ribonucleotide reductase null mutants induce lesions in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

The Pathogenicity of Ribonucleotide Reductase-Null Mutants of Herpes Simplex Virus Type 1 in Mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-3542%2898%2900016-3

7 January 2021

10.1016/S0166-3542(98)00016-3

Identifiers

DOI

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15 December 2017

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15 December 2017