Inducible regulation of Runx2-stimulated osteogenesis (Q45856301)

17 December 2017

title

Inducible regulation of Runx2-stimulated osteogenesis (English)

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17 December 2017

author name string

C A Gersbach

1

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17 December 2017

J M Le Doux

2

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17 December 2017

R E Guldberg

3

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17 December 2017

A J García

4

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17 December 2017

publication date

1 June 2006

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

13

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17 December 2017

issue

11

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17 December 2017

page(s)

873-882

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.gt.3302725

exact match

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Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro

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Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo

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Transplantation of skin fibroblasts expressing BMP-2 promotes bone repair more effectively than those expressing Runx2

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Engineered human mesenchymal stem cells: a novel platform for skeletal cell mediated gene therapy

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In Vitro andIn Vivo induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene

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BMP gene delivery for alveolar bone engineering at dental implant defects.

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Efficient BMP2 gene transfer and bone formation of mesenchymal stem cells by a fiber-mutant adenoviral vector

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Ectopic osteogenesis using adenoviral bone morphogenetic protein (BMP)-4 and BMP-6 gene transfer.

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Lentivirus-mediated gene transfer induces long-term transgene expression of BMP-2 in vitro and new bone formation in vivo

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Cbfa1/osf2 Transduced Bone Marrow Stromal Cells Facilitate Bone Formation In Vitro and In Vivo

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7 January 2021

Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization

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Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo

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Effects of Runx2 genetic engineering and in vitro maturation of tissue-engineered constructs on the repair of critical size bone defects.

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Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4.

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Regulatable gene expression systems for gene therapy applications: progress and future challenges

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

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Transcriptional activation by tetracyclines in mammalian cells

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The tet-off system is more effective than the tet-on system for regulating transgene expression in a single adenovirus vector

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Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system.

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7 January 2021

Development of a self-inactivating tet-on retroviral vector expressing bone morphogenetic protein 4 to achieve regulated bone formation

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Bone morphogenetic proteins: an update on basic biology and clinical relevance

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

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Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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7 January 2021

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

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7 January 2021

Gene therapy approaches for bone regeneration

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7 January 2021

Cell-type-dependent up-regulation of in vitro mineralization after overexpression of the osteoblast-specific transcription factor Runx2/Cbfal

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7 January 2021

Exogenous Runx2 expression enhances in vitro osteoblastic differentiation and mineralization in primary bone marrow stromal cells

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7 January 2021

Runx2/Cbfa1 stimulates transdifferentiation of primary skeletal myoblasts into a mineralizing osteoblastic phenotype.

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7 January 2021

Retroviral vectors applied to gene regulation studies

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7 January 2021

Anhydrotetracycline, a novel effector for tetracycline controlled gene expression systems in eukaryotic cells

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7 January 2021

Effects of medium perfusion rate on cell-seeded three-dimensional bone constructs in vitro

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7 January 2021

von Kossa staining alone is not sufficient to confirm that mineralization in vitro represents bone formation

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7 January 2021

Functional cooperativity between osteoblast transcription factors: evidence for the importance of subnuclear macromolecular complexes?

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7 January 2021

In vitro and in vivo synergistic interactions between the Runx2/Cbfa1 transcription factor and bone morphogenetic protein-2 in stimulating osteoblast differentiation

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7 January 2021

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity

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Tight control of gene expression by a helper-dependent adenovirus vector carrying the rtTA2(s)-M2 tetracycline transactivator and repressor system.

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Combinatorial gene therapy for bone regeneration: cooperative interactions between adenovirus vectors expressing bone morphogenetic proteins 2, 4, and 7.

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302725

7 January 2021

Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.

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7 January 2021

Local immunomodulation with CD4 and CD8 antibodies, but not cyclosporine A, improves osteogenesis induced by ADhBMP9 gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302725

7 January 2021

Simple and effective osteoinductive gene therapy by local injection of a bone morphogenetic protein-2-expressing recombinant adenoviral vector and FK506 mixture in rats

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302725

7 January 2021

Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302725

7 January 2021

High-efficiency retroviral infection of primary myoblasts

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https://api.crossref.org/works/10.1038%2FSJ.GT.3302725

7 January 2021

Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3302725

7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302725

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17 December 2017

Dimensions Publication ID

0 references

1 reference

17 December 2017