Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial (Q45859665)

17 December 2017

title

Adenovector-mediated gene delivery of interleukin-2 in metastatic breast cancer and melanoma: results of a phase 1 clinical trial (English)

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17 December 2017

main subject

phase I clinical trial

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metastatic breast cancer

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Stewart AK

1

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17 December 2017

Lassam NJ

2

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Quirt IC

3

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17 December 2017

Bailey DJ

4

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17 December 2017

Rotstein LE

5

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Krajden M

6

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17 December 2017

Dessureault S

7

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Gallinger S

8

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Cappe D

9

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17 December 2017

Wan Y

10

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Addison CL

11

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Moen RC

12

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Gauldie J

13

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Graham FL

14

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publication date

1 March 1999

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

6

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issue

3

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17 December 2017

page(s)

350-363

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17 December 2017

Safety of in vivo adenovirus-mediated thymidine kinase treatment of oral cancer

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Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination

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Phase I study of a recombinant adenovirus-mediated gene transfer in lung cancer patients

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Tumour immunotherapy using an adenoviral vector expressing a membrane-bound mutant of murine TNF alpha

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Direct Intratumoral Injection of an Adenovirus Expressing Interleukin-12 Induces Regression and Long-Lasting Immunity That Is Associated with Highly Localized Expression of Interleukin-12

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Interleukin 12 and B7-1 costimulatory molecule expressed by an adenovirus vector act synergistically to facilitate tumor regression

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Human gene marker/therapy clinical protocols

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7 January 2021

A phase I study of adenovirus mediated gene transfer of interleukin 2 cDNA into metastatic breast cancer or melanoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.GT.3300833

7 January 2021

Immune response to recombinant capsid proteins of adenovirus in humans: antifiber and anti-penton base antibodies have a synergistic effect on neutralizing activity.

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7 January 2021

Anti-metastatic vaccination of tumor-bearing mice with IL-2-gene-inserted tumor cells

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7 January 2021

Induction of tumor-specific cytotoxic T lymphocytes and natural killer cells by tumor cells transfected with the interleukin-2 gene

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3300833

1 reference

17 December 2017

Dimensions Publication ID

1012269301

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17 December 2017