Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates (Q45863393)

17 December 2017

title

Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates (English)

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17 December 2017

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Julia Lanciotti

1

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17 December 2017

Antonius Song

2

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17 December 2017

John Doukas

3

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17 December 2017

Barbara Sosnowski

4

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17 December 2017

Glenn Pierce

5

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17 December 2017

Richard Gregory

6

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17 December 2017

Samuel Wadsworth

7

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17 December 2017

Catherine O'Riordan

8

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17 December 2017

publication date

1 July 2003

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17 December 2017

published in

Molecular Therapy

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17 December 2017

volume

8

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17 December 2017

issue

1

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17 December 2017

page(s)

99-107

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17 December 2017

Modification of an adenoviral vector with biologically selected peptides: a novel strategy for gene delivery to cells of choice

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A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo

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Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies.

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Polylysine modification of adenoviral fiber protein enhances muscle cell transduction

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7 January 2021

Insertion of an RGD motif into the HI loop of adenovirus fiber protein alters the distribution of transgene expression of the systemically administered vector

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Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions

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PEGylation of adenovirus with retention of infectivity and protection from neutralizing antibody in vitro and in vivo.

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"Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung

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Adenovirus DNA. I. Molecular weight and conformation

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7 January 2021

Structural properties of adenovirus DNA's

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7 January 2021

Reducing the heterogeneity of chemically conjugated targeted toxins: homogeneous basic FGF-saporin

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7 January 2021

Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta

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7 January 2021

Retargeted delivery of adenoviral vectors through fibroblast growth factor receptors involves unique cellular pathways.

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Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

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Characterization of factors involved in modulating persistence of transgene expression from recombinant adenovirus in the mouse lung

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7 January 2021

Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo

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Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

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7 January 2021

Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

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7 January 2021

Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ

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7 January 2021

Reduced immunogenicity of monomethoxypolyethylene glycol-modified lysozyme for activation of T cells

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7 January 2021

E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors

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7 January 2021

Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis

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7 January 2021

Molecular characterization of replication-competent variants of adenovirus vectors and genome modifications to prevent their occurrence

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7 January 2021

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The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12

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7 January 2021

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Identifiers

DOI

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17 December 2017

PubMed ID

12842433

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17 December 2017