Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension (Q45865709)

17 December 2017

title

Bone morphogenetic protein type 2 receptor gene therapy attenuates hypoxic pulmonary hypertension (English)

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17 December 2017

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Nicholas W Morrell

7

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David T. Curiel

6

object named as

David T Curiel

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17 December 2017

Ann M Reynolds

1

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Wei Xia

2

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Mark D Holmes

3

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Sandra J Hodge

4

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Sergei Danilov

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Paul N Reynolds

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publication date

2 February 2007

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American Journal of Physiology - Lung Cellular and Molecular Physiology

published in

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volume

292

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page(s)

L1182-92

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issue

5

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Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor

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BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia.

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Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

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Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension.

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Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia

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Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter

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Survival with first-line bosentan in patients with primary pulmonary hypertension.

21 January 2018

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Targeting endothelial cells with adenovirus expressing nitric oxide synthase prevents elevation of blood pressure in stroke-prone spontaneously hypertensive rats

21 January 2018

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Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

21 January 2018

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Ablating adenovirus type 5 fiber-CAR binding and HI loop insertion of the SIGYPLP peptide generate an endothelial cell-selective adenovirus

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Combined transductional and transcriptional targeting improves the specificity of transgene expression in vivo

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A targetable, injectable adenoviral vector for selective gene delivery to pulmonary endothelium in vivo

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Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

21 January 2018

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Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity.

21 January 2018

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Survival in patients with class III idiopathic pulmonary arterial hypertension treated with first line oral bosentan compared with an historical cohort of patients started on intravenous epoprostenol

21 January 2018

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Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice

21 January 2018

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Bone morphogenetic protein receptor-2 signaling promotes pulmonary arterial endothelial cell survival: implications for loss-of-function mutations in the pathogenesis of pulmonary hypertension.

21 January 2018

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Inhibition of matrix metalloproteinases by lung TIMP-1 gene transfer limits monocrotaline-induced pulmonary vascular remodeling in rats

21 January 2018

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Improved vascular gene transfer with a helper-dependent adenoviral vector

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Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle

21 January 2018

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Use of phage display to identify novel peptides for targeted gene therapy

21 January 2018

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Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial Hypertension

21 January 2018

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Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension

21 January 2018

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10.1152/AJPLUNG.00020.2006

21 January 2018

Identifiers

DOI

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17 December 2017

PubMed ID

17277049

1 reference

17 December 2017