P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells (Q45871082)

17 December 2017

review article

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title

P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells (English)

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17 December 2017

main subject

multiple drug resistance

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T Licht

1

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17 December 2017

I Pastan

series ordinal

2

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17 December 2017

M Gottesman

series ordinal

3

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17 December 2017

F Herrmann

series ordinal

4

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17 December 2017

publication date

1 October 1994

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17 December 2017

published in

Annals of Hematology

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17 December 2017

volume

69

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17 December 2017

issue

4

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17 December 2017

page(s)

159-171

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17 December 2017

Expression of the Multidrug Transporter P-Glycoprotein and In Vitro Chemosensitivity: Correlation with In Vivo Response to Chemotherapy in Acute Myeloid Leukemia

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P-glycoprotein expression in normal and reactive bone marrows

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Synergistic effect of cyclosporin A and verapamil in overcoming vincristine resistance of multidrug-resistant cultured human leukemia cells

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A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

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21 January 2018

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Different types of non-P-glycoprotein mediated multiple drug resistance in children with relapsed acute lymphoblastic leukaemia

21 January 2018

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Regulation of initial vinblastine influx by P-glycoprotein

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Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein

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Alternating versus hybrid MOPP-ABVD in Hodgkin’s disease: The Milan experience

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Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

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P-glycoprotein expression in primary breast cancer detected by immunocytochemistry with two monoclonal antibodies

21 January 2018

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Multidrug resistance mediated by P-glycoproteins

21 January 2018

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12 December 2020

PCR-determined expression of the MDR1 gene in chronic lymphocytic leukemia

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12 December 2020

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia

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12 December 2020

Flow cytometric analysis of P-glycoprotein in normal and leukemic cells

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12 December 2020

Expression of multidrug resistance P-glycoprotein on peripheral blood mononuclear cells of patients with granular lymphocyte-proliferative disorders

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12 December 2020

Expression of the mdr3 gene in prolymphocytic leukemia: association with cyclosporin-A-induced increase in drug accumulation

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12 December 2020

Clinical trials of agents that reverse multidrug resistance. A literature review

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12 December 2020

Cytotoxic and cytostatic effects of antitumor agents induced at the plasma membrane level

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12 December 2020

Exploring multidrug resistance using rhodamine 123.

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12 December 2020

Deletion and insertion mutants of the multidrug transporter.

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12 December 2020

Binding properties of monoclonal antibodies recognizing external epitopes of the human MDR1 P-glycoprotein.

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12 December 2020

MDR1 RNA expression is an independent prognostic factor in acute myeloid leukemia

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12 December 2020

Genetic aspects of multidrug resistance

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12 December 2020

Distribution of multi-drug resistance-associated P-glycoprotein in normal and neoplastic human tissues. Analysis with 3 monoclonal antibodies recognizing different epitopes of the P-glycoprotein molecule

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12 December 2020

Immunohistochemical detection of the multidrug transport protein P1 70 in human normal tissues and malignant lymphomas

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12 December 2020

Cleavage of human MDR1 mRNA by a hammerhead ribozyme

1 reference

12 December 2020

Elimination of drug-resistant myeloma tumor cell lines by monoclonal anti-P-glycoprotein antibody and rabbit complement

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12 December 2020

ATP and GTP as alternative energy sources for vinblastine transport by P-170 in KB-V1 plasma membrane vesicles

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12 December 2020

Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells

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12 December 2020

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

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12 December 2020

P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high-dose verapamil

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12 December 2020

Relevance of mdr1 gene expression in acute myeloid leukemia and comparison of different diagnostic methods

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12 December 2020

Effect of transient hypoxia on sensitivity to doxorubicin in human and murine cell lines

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12 December 2020

Reversal of drug resistance by erythromycin: erythromycin increases the accumulation of actinomycin D and doxorubicin in multidrug-resistant cells.

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12 December 2020

Reversal of multi-drug resistance in human KB cell lines by structural analogs of verapamil

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12 December 2020

Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukaemia.

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12 December 2020

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

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12 December 2020

The transporters associated with antigen presentation

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12 December 2020

Doxorubicin resistance in P388 leukemia--evidence for reduced drug influx.

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12 December 2020

Demonstration That CFTR Is a Chloride Channel by Alteration of Its Anion Selectivity

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12 December 2020

Amiodarone-induced enhancement of doxorubicin and 4'-deoxydoxorubicin cytotoxicity to rat colon cancer cells in vitro and in vivo.

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12 December 2020

Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells

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12 December 2020

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis

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12 December 2020

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction

1 reference

12 December 2020

Expression of a multidrug resistance gene in human cancers

1 reference

12 December 2020

Effects of reoxygenation on cells from hypoxic regions of solid tumors: anticancer drug sensitivity and metastatic potential.

1 reference

12 December 2020

Expression of the multidrug transporter, P-glycoprotein, in acute leukemia cells and correlation to clinical drug resistance.

1 reference

12 December 2020

Synergistic inhibition by verapamil and quinine of P-glycoprotein-mediated multidrug resistance in a human myeloma cell line model

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12 December 2020

Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

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12 December 2020

Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16

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12 December 2020

Multidrug-resistant myeloma: laboratory and clinical effects of verapamil as a chemosensitizer

1 reference

12 December 2020

High-level expression of P-glycoprotein and 85 kD protein as assessed by flow cytometry and immunocytochemistry in leukemias and malignant lymphomas

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12 December 2020

Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

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12 December 2020

Differentiation dependent expression of P-glycoprotein in the normal and neoplastic human kidney

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12 December 2020

Biochemistry of multidrug resistance mediated by the multidrug transporter

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12 December 2020

Drug-resistance in multiple myeloma and non-Hodgkin's lymphoma: detection of P-glycoprotein and potential circumvention by addition of verapamil to chemotherapy.

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12 December 2020

P-glycoprotein-mediated multidrug resistance and cytotoxic effector cells

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12 December 2020

P-glycoprotein expression in human plasma cell myeloma: correlation with prior chemotherapy.

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12 December 2020

Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1

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12 December 2020

Tumor hypoxia, drug resistance, and metastases

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12 December 2020

Pseudomonas exotoxin conjugated to monoclonal antibody MRK16 specifically kills multidrug resistant cells in cultured renal carcinomas and in MDR-transgenic mice

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12 December 2020

Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas

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12 December 2020

MDR1 gene expression and treatment outcome in acute myeloid leukemia.

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12 December 2020

Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells

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12 December 2020

Expression of P-glycoprotein and anionic glutathione S-transferase genes in non-Hodgkin's lymphoma.

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12 December 2020

Molecular analysis of the multidrug transporter

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12 December 2020

Reciprocal correlation between expression of P-glycoprotein and accumulation of rhodamine 123 in human tumors.

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12 December 2020

Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.

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12 December 2020

Glutathione transferases and cancer

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12 December 2020

Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance

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12 December 2020

P-glycoproteins: mediators of multidrug resistance

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12 December 2020

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells

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12 December 2020

Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis

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12 December 2020

Various methods of analysis of mdr-1/P-glycoprotein in human colon cancer cell lines

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12 December 2020

Multiple-drug resistance in human cancer

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12 December 2020

MDR1 gene expression in lung cancer.

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12 December 2020

Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein

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12 December 2020

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice

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12 December 2020

Induction of multiple-drug resistance during anti-neoplastic chemotherapy in vitro

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12 December 2020

Expression of P-glycoprotein in adult T-cell leukemia cells

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12 December 2020

Glutathione metabolism and its selective modification

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12 December 2020

MDR-1 expression and response to vincristine, doxorubicin, and dexamethasone chemotherapy in multiple myeloma refractory to alkylating agents.

1 reference

12 December 2020

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues

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12 December 2020

Expression of the multidrug resistance gene product (P-glycoprotein) in myelodysplasia is associated with a stem cell phenotype

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12 December 2020

The role of glutathione-dependent enzymes in drug resistance

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12 December 2020

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells

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12 December 2020

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

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12 December 2020

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood

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12 December 2020

Common expression of the multidrug resistance marker P-glycoprotein in B-cell chronic lymphocytic leukaemia and correlation with in vitro drug resistance

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12 December 2020

Structure of the human MDR3 gene and physical mapping of the human MDR locus

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12 December 2020

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites

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12 December 2020

Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells

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12 December 2020

The role of topoisomerase II in drug resistance

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12 December 2020

Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining

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12 December 2020

Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1 reference

12 December 2020

Immunohistochemical detection and quantitation of P-glycoprotein in multiple drug-resistant human myeloma cells: association with level of drug resistance and drug accumulation

1 reference

12 December 2020

Characteristics of Multidrug Resistance in Plasmodium and Leishmania: Detection of P-Glycoprotein-Like Components

1 reference

12 December 2020

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1 reference

12 December 2020

Comparison of western blot analysis and immunocytochemical detection of P-glycoprotein in multidrug resistant cells

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12 December 2020

Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines.

1 reference

12 December 2020

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

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12 December 2020

Expression of MDR1 gene in acute leukemia cells: association with CD7+ acute myeloblastic leukemia/acute lymphoblastic leukemia

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12 December 2020

Mechanism of multidrug resistance

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12 December 2020

Exposure to lipophilic industrial solvents leads to increased P-glycoprotein expression in peripheral blood cells

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12 December 2020

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil

1 reference

12 December 2020

Increased effectiveness of liposome-encapsulated doxorubicin in multidrug-resistant-transgenic mice compared with free doxorubicin

1 reference

12 December 2020

Characterization of the human MDR3 P-glycoprotein and its recognition by P-glycoprotein-specific monoclonal antibodies

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12 December 2020

High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia

1 reference

12 December 2020

Multidrug-resistance phenotype of a subpopulation of T-lymphocytes without drug selection

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12 December 2020

Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia

1 reference

12 December 2020

Transfer and expression of the human multidrug resistance gene in mouse erythroleukemia cells

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12 December 2020

Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule

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12 December 2020

Activity of P-glycoprotein in B-cell chronic lymphocytic leukemia determined by a flow cytometric assay

1 reference

12 December 2020

P-glycoprotein expression in plasma-cell myeloma is associated with resistance to VAD.

1 reference

12 December 2020

Modulation of multidrug-resistant multiple myeloma by cyclosporin. The Leukaemia Group of the EORTC and the HOVON

1 reference

12 December 2020

Genomic organization of the human multidrug resistance (MDR1) gene and origin of P-glycoproteins

1 reference

12 December 2020

Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)

1 reference

12 December 2020

Expression of the multidrug resistance gene in myeloid leukemias.

1 reference

12 December 2020

Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes

1 reference

12 December 2020

Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins

1 reference

12 December 2020

Expression of the proliferation-associated Ki-67 antigen of transferrin receptors and of DNA polymerase? in human tumour lines: implications for in vitro chemoresistance

1 reference

12 December 2020

High expression of the multidrug resistance P-glycoprotein in high-risk myelodysplasia is associated with immature phenotype.

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12 December 2020

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody

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12 December 2020

SDZ PSC 833, a non-immunosuppressive cyclosporine: its potency in overcoming P-glycoprotein-mediated multidrug resistance of murine leukemia

1 reference

12 December 2020

Genetic transfer of non-P-glycoprotein-mediated multidrug resistance (MDR) in somatic cell fusion: dissection of a compound MDR phenotype

1 reference

12 December 2020

Efficient gene transfer in live mice using a unique retroviral packaging line

1 reference

12 December 2020

In vitro response of human small-cell lung-cancer cell lines to chemotherapeutic drugs; no correlation with clinical data

1 reference

12 December 2020

Markedly altered membrane transport and intracellular binding of vincristine in multidrug-resistant Chinese hamster cells selected for resistance to vinca alkaloids.

1 reference

12 December 2020

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

1 reference

12 December 2020

Expression of a multidrug-resistance gene in human tumors and tissues

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12 December 2020

Clinical trials of modulation of multidrug resistance. Pharmacokinetic and pharmacodynamic considerations

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12 December 2020

Effect of liposomes on P-glycoprotein function in multidrug resistant cells

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12 December 2020

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities

1 reference

12 December 2020

Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas

1 reference

12 December 2020

Relationship of the expression of the multidrug resistance gene product (P-glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis

1 reference

12 December 2020

Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity

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12 December 2020

Induction of multidrug resistance in human cells by transient exposure to different chemotherapeutic drugs.

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12 December 2020

Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype

1 reference

12 December 2020

Collateral sensitivity to nitrosoureas in multidrug-resistant cells selected with verapamil

1 reference

12 December 2020

Mechanisms of multidrug resistance in cancer treatment

1 reference

12 December 2020

Reversal by cefoperazone of resistance to etoposide, doxorubicin, and vinblastine in multidrug resistant human sarcoma cells

1 reference

12 December 2020

In vitro effect of P-glycoprotein (P-gp) modulators on drug sensitivity of leukemic progenitors (CFU-L) in acute myelogenous leukemia (AML)

1 reference

12 December 2020

Serial transplantation shows that early hematopoietic precursor cells are transduced by MDR-1 retroviral vector in a mouse gene therapy model

1 reference

12 December 2020

Use of fluorescent dyes as molecular probes for the study of multidrug resistance

1 reference

12 December 2020

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1 reference

12 December 2020

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1 reference

12 December 2020

Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells

1 reference

12 December 2020

Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications.

1 reference

12 December 2020

Magnetic-Affinity Cell Sorting of Human Multidrug-Resistant Cells

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12 December 2020

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells

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12 December 2020

Transfer and expression of the human multiple drug resistance gene into live mice

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12 December 2020

Effects of tumor necrosis factor on sensitive and multidrug resistant human leukemia and myeloma cell lines.

1 reference

12 December 2020

Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport

1 reference

12 December 2020

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1 reference

12 December 2020

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells

1 reference

12 December 2020

N-(5,5-diacetoxypent-1-yl)doxorubicin: a new intensely potent doxorubicin analogue

1 reference

12 December 2020

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1 reference

12 December 2020

Analysis of multidrug resistance (MDR-1) gene expression in chronic lymphocytic leukaemia (CLL)

1 reference

12 December 2020

Expression of the multidrug transporter, P-glycoprotein, in chronic myelogenous leukaemia cells in blast crisis.

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12 December 2020

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

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12 December 2020

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

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12 December 2020

Mammalian multidrug-resistance gene: correlation of exon organization with structural domains and duplication of an ancestral gene

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12 December 2020

Identifiers

DOI

10.1007/BF02215949

1 reference

17 December 2017

1 reference

17 December 2017