Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides (Q45877030)

17 December 2017

title

Long-term transgene expression from plasmid DNA gene therapy vectors is negatively affected by CpG dinucleotides (English)

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17 December 2017

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Bradley L Hodges

1

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17 December 2017

Kristin M Taylor

2

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17 December 2017

Macy F Joseph

3

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17 December 2017

Sarah A Bourgeois

4

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17 December 2017

Ronald K Scheule

5

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17 December 2017

publication date

1 August 2004

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17 December 2017

published in

Molecular Therapy

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17 December 2017

volume

10

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17 December 2017

issue

2

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17 December 2017

page(s)

269-278

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17 December 2017

Gene silencing as a threat to the success of gene therapy

cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Long-term expression of human alpha1-antitrypsin gene in mouse liver achieved by intravenous administration of plasmid DNA using a hydrodynamics-based procedure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Time course of gene expression after plasmid DNA gene transfer to the liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Reduced inflammatory response to plasmid DNA vectors by elimination and inhibition of immunostimulatory CpG motifs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA Complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

CpG-depleted plasmid DNA vectors with enhanced safety and long-term gene expression in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Linear DNAs concatemerize in vivo and result in sustained transgene expression in mouse liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Optimization of cis-acting elements for gene expression from nonviral vectors in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Free DNA ends are essential for concatemerization of synthetic double-stranded adeno-associated virus vector genomes transfected into mouse hepatocytes in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Demonstration of feasibility of in vivo gene therapy for Gaucher disease using a chemically induced mouse model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Cellular gene dose and kinetics of gene expression in mouse livers transfected by high-volume tail-vein injection of naked DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Hydrodynamic delivery of DNA.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Sodium phosphate enhances plasmid DNA expression in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Direct gene transfer into nonhuman primate myofibers in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Inclusion of the hepatic locus control region, an intron, and untranslated region increases and stabilizes hepatic factor IX gene expression in vivo but not in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

7 January 2021

Imprinting mechanisms.

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Methyl-CpG-binding protein 2 represses LINE-1 expression and retrotransposition but not Alu transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Molecular mechanisms of gene silencing mediated by DNA methylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

A Toll-like receptor recognizes bacterial DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

The DNA methyltransferases of mammals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Methyl CpG binding proteins: coupling chromatin architecture to gene regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Methylation-mediated proviral silencing is associated with MeCP2 recruitment and localized histone H3 deacetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Regulation of transcription and chromatin by methyl-CpG binding protein MBD1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Epigenetics: interaction of DNA methylation and chromatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Identification and characterization of a family of mammalian methyl-CpG binding proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Multiply deleted [E1, polymerase-, and pTP-] adenovirus vector persists despite deletion of the preterminal protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

The effect of CpG sequences on the B cell response to a viral glycoprotein encoded by a plasmid vector

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

CpG methylation of a plasmid vector results in extended transgene product expression by circumventing induction of immune responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Recruitment of single-stranded recombinant adeno-associated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Extrachromosomal recombinant adeno-associated virus vector genomes are primarily responsible for stable liver transduction in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

DNA methylation has a local effect on transcription and histone acetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

Implication of interfering antibody formation and apoptosis as two different mechanisms leading to variable duration of adenovirus-mediated transgene expression in immune-competent mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMTHE.2004.04.018

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YMTHE.2004.04.018

1 reference

17 December 2017

PubMed ID

15294174

1 reference

17 December 2017