Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts (Q45877347)

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scientific article published in July 1996

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English	Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts	scientific article published in July 1996

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scholarly article

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Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/8699255

Double transduction with GTP cyclohydrolase I and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts (English)

1 reference

Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/8699255

6

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15 May 2020

author name string

C Bencsics

1

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15 May 2020

S R Wachtel

2

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15 May 2020

S Milstien

3

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15 May 2020

K Hatakeyama

4

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15 May 2020

J B Becker

5

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15 May 2020

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publication date

1 July 1996

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Europe PubMed Central

17 December 2017

http://europepmc.org/abstract/MED/8699255

Journal of Neuroscience

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15 May 2020

16

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15 May 2020

14

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15 May 2020

4449-4456

1 reference

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15 May 2020

Entrance of tetrahydropterin derivatives in brain after peripheral administration: effect on biogenic amine metabolism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Behavioral effects and gene delivery in a rat model of Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test

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Biopterin. III. Purification and characterization of enzymes involved in the cerebral synthesis of 7,8-dihydrobiopterin

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Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce l-dopa

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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L-3,4-dihydroxyphenylalanine-induced dopamine release in the striatum of intact and 6-hydroxydopamine-treated rats: differential effects of monoamine oxidase A and B inhibitors.

1 reference

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12 December 2020

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Use of microdialysis for monitoring tyrosine hydroxylase activity in the brain of conscious rats

1 reference

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12 December 2020

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Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain

1 reference

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12 December 2020

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Tetrahydrobiopterin in Striatum: Localization in Dopamine Nerve Terminals and Role in Catecholamine Synthesis

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12 December 2020

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Microdialysis monitoring of 3,4-dihydroxyphenylalanine accumulation after decarboxylase inhibition: a means to estimate in vivo changes in tyrosine hydroxylase activity of the rat locus ceruleus.

1 reference

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12 December 2020

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Tetrahydrobiopterin turnover in cultured rat sympathetic neurons: developmental profile, pharmacologic sensitivity, and relationship to norepinephrine synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Analysis of reduced forms of biopterin in biological tissues and fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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Biopterin cofactor and monoamine-synthesizing monooxygenases

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https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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An HSV-1 vector expressing tyrosine hydroxylase causes production and release of L-dopa from cultured rat striatal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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L-3,4-dihydroxyphenylalanine synthesis by genetically modified Schwann cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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The stability of endogenous tyrosine hydroxylase protein in PC-12 cells differs from that expressed in mouse fibroblasts by gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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A RAPID AND SIMPLE RADIOASSAY FOR TYROSINE HYDROXYLASE ACTIVITY

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Elevated body swing test: a new behavioral parameter for rats with 6-hydroxydopamine-induced hemiparkinsonism

1 reference

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12 December 2020

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Brain-derived neurotrophic factor-transduced fibroblasts: production of BDNF and effects of grafting to the adult rat brain.

1 reference

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12 December 2020

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Effect of (6R)- and (6S)-tetrahydrobiopterin on L-3,4-dihydroxyphenylalanine (DOPA) formation in NRK fibroblasts transfected with human tyrosine hydroxylase type 2 cDNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Cloning and sequencing of cDNA encoding rat GTP cyclohydrolase I. The first enzyme of the tetrahydrobiopterin biosynthetic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Peripherally Administered Reduced Pterins Do Enter the Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Improved retroviral vectors for gene transfer and expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Adrenal medulla grafts in the hemiparkinsonian rat: profile of behavioral recovery predicts restoration of the symmetry between the two striata in measures of pre- and postsynaptic dopamine function

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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Neural-targeted gene therapy for rodent and primate hemiparkinsonism

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Morphological and neurochemical features of cultured primary skin fibroblasts of Fischer 344 rats following striatal implantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively prese

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetrahydrobiopterin-dependent functional recovery in 6-hydroxydopamine-treated rats by intracerebral grafting of fibroblasts transfected with tyrosine hydroxylase cDNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

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Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

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Regulation of dopamine production by genetically modified primary fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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The use of adenovirus vectors for intracerebral grafting of transfected nervous cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biopterin cofactor biosynthesis: GTP cyclohydrolase, neopterin and biopterin in tissues and body fluids of mammalian species

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetrahydrobiopterin is required for cytokine-induced nitric oxide production in a murine macrophage cell line (RAW 264).

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postsynaptic supersensitivity after 6-hydroxy-dopamine induced degeneration of the nigro-striatal dopamine system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of L-3,4-dihydroxyphenylalanine by tyrosine hydroxylase cDNA-transfected C6 cells: application for intracerebral grafting

1 reference

https://pubmed.ncbi.nlm.nih.gov/8699255

12 December 2020

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Identifiers

10.1523/JNEUROSCI.16-14-04449.1996

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6578851&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6578851&resulttype=core&format=json

15 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6578851&resulttype=core&format=json

15 May 2020

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