Engineering human chromosomes for gene therapy studies (Q45877499)

17 December 2017

title

Engineering human chromosomes for gene therapy studies (English)

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17 December 2017

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Choo KH

1

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17 December 2017

publication date

1 June 2001

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17 December 2017

Trends in Molecular Medicine

published in

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17 December 2017

volume

7

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17 December 2017

issue

6

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17 December 2017

page(s)

235-237

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17 December 2017

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

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Human artificial chromosomes generated by modification of a yeast artificial chromosome containing both human alpha satellite and single-copy DNA sequences.

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Genomics and gene therapy. Artificial chromosomes coming to life

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De novo chromosome formations by large-scale amplification of the centromeric region of mouse chromosomes

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Generation of a human X-derived minichromosome using telomere-associated chromosome fragmentation.

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Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage

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Centromere DNA dynamics: latent centromeres and neocentromere formation

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Construction of neocentromere-based human minichromosomes by telomere-associated chromosomal truncation.

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Transfer of YACs up to 2.3 Mb intact into human cells with polyethylenimine

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Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection.

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Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.

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A structurally defined mini-chromosome vector for the mouse germ line.

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Cloning of male mice from adult tail-tip cells.

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Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells.

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Artificial chromosomes: ideal vectors?

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Identifiers

DOI

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17 December 2017

release_dv3liuklhnhd7f3qxwyy2w557q

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/dv3liuklhnhd7f3qxwyy2w557q

24 November 2022

mapped directly with Wikidata item

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17 December 2017