Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy (Q45883662)

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English	Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/15905856

Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy (English)

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/15905856

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hepatocellular carcinoma

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Daniëlle A M Heideman

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object named as

Daniëlle A M Heideman

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Europe PubMed Central

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Chris J L M Meijer

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object named as

Chris J L M Meijer

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Europe PubMed Central

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Peter J F Snijders

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object named as

Peter J F Snijders

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Europe PubMed Central

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17 December 2017

http://europepmc.org/abstract/MED/15905856

author name string

Renée M Overmeer

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Victor W van Beusechem

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Wouter H Lamers

4

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Theodorus B M Hakvoort

5

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Mikael E Craanen

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17 December 2017

http://europepmc.org/abstract/MED/15905856

G Johan A Offerhaus

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Winald R Gerritsen

10

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17 December 2017

http://europepmc.org/abstract/MED/15905856

publication date

1 December 2005

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Europe PubMed Central

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17 December 2017

http://europepmc.org/abstract/MED/15905856

Cancer Gene Therapy

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17 December 2017

http://europepmc.org/abstract/MED/15905856

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Europe PubMed Central

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17 December 2017

http://europepmc.org/abstract/MED/15905856

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1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/15905856

954-962

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/15905856

NK4 (HGF-antagonist/angiogenesis inhibitor) in cancer biology and therapeutics

1 reference

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21 January 2018

Targeting angiogenesis and HGF function using an adenoviral vector expressing the HGF antagonist NK4 for cancer therapy

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Tumor suppression effect using NK4, a molecule acting as an antagonist of HGF, on human gastric carcinomas.

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Gene transduction of NK4, HGF antagonist, inhibits in vitro invasion and in vivo growth of human pancreatic cancer.

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Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice.

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21 January 2018

Suppression of tumor growth, invasion and angiogenesis of human gastric cancer by adenovirus-mediated expression of NK4.

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Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression.

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Adenoviral-mediated gene transduction of the hepatocyte growth factor (HGF) antagonist, NK4, suppresses peritoneal metastases of gastric cancer in nude mice

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Suppression of the progress of disseminated pancreatic cancer cells by NK4 plasmid DNA released from cationized gelatin microspheres.

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Gallbladder cancer treatment using adenovirus expressing the HGF/NK4 gene in a peritoneal implantation model.

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Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice

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21 January 2018

The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo.

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Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist

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21 January 2018

Gene expression of hepatocyte growth factor and its receptor in HCC and nontumorous liver tissues

1 reference

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21 January 2018

Expression of HGF, its receptor c-met, c-myc, and albumin in cirrhotic and neoplastic human liver tissue

1 reference

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21 January 2018

Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine

1 reference

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Hepatocyte growth factor has potent anti-proliferative activity in various tumor cell lines

1 reference

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21 January 2018

Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells

1 reference

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21 January 2018

Human hepatic myofibroblasts increase invasiveness of hepatocellular carcinoma cells: evidence for a role of hepatocyte growth factor

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21 January 2018

Hepatocyte growth factor inhibits cell proliferation in vivo of rat hepatocellular carcinomas induced by diethylnitrosamine

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Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model

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Maintenance of vascular endothelial cell-specific properties after immortalization with an amphotrophic replication-deficient retrovirus containing human papilloma virus 16 E6/E7 DNA.

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Absence of tpr-met and expression of c-met in human gastric mucosa and carcinoma.

1 reference

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21 January 2018

Concomitant expression of hepatocyte growth factor/scatter factor and the receptor c-MET in human myeloma cell lines

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Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition

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21 January 2018

HGF/NK4 inhibited VEGF-induced angiogenesis in in vitro cultured endothelial cells and in vivo rabbit model.

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21 January 2018

Replicative adenoviruses for cancer therapy

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Replication-selective adenoviruses as oncolytic agents

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Effective gene therapy for pancreatic cancer by cytokines mediated by restricted replication-competent adenovirus

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21 January 2018

Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer

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Antiangiogenic gene therapy

1 reference

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21 January 2018

HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor

1 reference

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7 January 2021

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Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

1 reference

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u-PA and c-MET mRNA expression is co-ordinately enhanced while hepatocyte growth factor mRNA is down-regulated in human hepatocellular carcinoma

1 reference

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Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study

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Expression of hepatocyte growth factor and its receptor, the c-met proto-oncogene, in hepatocellular carcinoma

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Human hepatocyte growth factor stimulates the growth of HuH-6 clone 5 human hepatoblastoma cells

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Kringle 1-4 of hepatocyte growth factor inhibits proliferation and migration of human microvascular endothelial cells

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Identifiers

10.1038/SJ.CGT.7700856

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/15905856

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0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/15905856

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