Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma (Q45884086)

17 December 2017

title

Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma (English)

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17 December 2017

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3

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17 December 2017

Mauro Provinciali

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17 December 2017

author name string

A Smorlesi

1

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17 December 2017

F Papalini

2

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17 December 2017

A Donnini

4

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17 December 2017

F Re

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17 December 2017

publication date

1 September 2005

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17 December 2017

published in

Gene Therapy

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17 December 2017

volume

12

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17 December 2017

issue

17

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17 December 2017

page(s)

1324-1332

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17 December 2017

https://scigraph.springernature.com/pub.10.1038/sj.gt.3302559

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cites work

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DNA vaccination with full-length or truncated neu induces protective immunity against the development of spontaneous mammary tumors in HER-2/neu transgenic mice

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Prevention of spontaneous neu-expressing mammary tumor development in mice transgenic for rat proto-neu by DNA vaccination.

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Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice.

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DNA vaccination against neu reduces breast cancer incidence and metastasis in mice

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Enhanced efficacy of DNA vaccination against Her-2/neu tumor antigen by genetic adjuvants

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Imiquimod and the imidazoquinolones: mechanism of action and therapeutic potential

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

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Immune modulation and apoptosis induction: two sides of the antitumoral activity of imiquimod

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Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery

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Imiquimod, a Toll-like receptor-7 agonist, induces perforin in cytotoxic T lymphocytes in vitro

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Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod

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Soluble cytokines can act as effective adjuvants in plasmid DNA vaccines targeting self tumor antigens

21 January 2018

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7 January 2021

Low effectiveness of DNA vaccination against HER-2/neu in ageing

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p185(neu) protein is required for tumor and anchorage-independent growth, not for cell proliferation of transgenic mammary carcinoma

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Optimization of cytotoxic assay by target cell retention of the fluorescent dye carboxyfluorescein diacetate (CFDA) and comparison with conventional 51CR release assay

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Calculation of lytic units for the expression of cell-mediated cytotoxicity

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7 January 2021

Identifiers

DOI

10.1038/SJ.GT.3302559

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17 December 2017

Dimensions Publication ID

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17 December 2017