Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake. (Q45969426)

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English	Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake.	scientific article

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31 January 2020

Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake (English)

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31 January 2020

phosphorylation

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Carina Rodrigues Boeck

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31 January 2020

Tetsade C Piermartiri

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31 January 2020

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31 January 2020

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Samuel Vandresen-Filho

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31 January 2020

Bruno de Araújo Herculano

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31 January 2020

Wagner C Martins

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31 January 2020

Denis Dal'agnolo

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31 January 2020

Ellen Stroeh

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31 January 2020

Cristiane Lima Carqueja

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2 May 2009

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31 January 2020

Neurotoxicity Research

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31 January 2020

16

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31 January 2020

106-115

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31 January 2020

2

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31 January 2020

https://scigraph.springernature.com/pub.10.1007/s12640-009-9057-6

0 references

Quinolinic Acid Concentrations in Brain and Cerebrospinal Fluid of Patients with Intractable Complex Partial Seizures

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9057-6

21 January 2018

Akt: versatile mediator of cell survival and beyond

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9057-6

21 January 2018

Cholesterol-independent effects of statins and new therapeutic targets: ischemic stroke and dementia

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9057-6

21 January 2018

Lovastatin reduces neuronal cell death in hippocampal CA1 subfield after pilocarpine-induced status epilepticus: preliminary results.

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9057-6

21 January 2018

Potential Role of Statins in Inflammation and Atherosclerosis

1 reference

https://api.crossref.org/works/10.1007%2FS12640-009-9057-6

21 January 2018

Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenines and Seizures

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Platelet-derived growth factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safety of high-dose atorvastatin therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Guanosine and GMP prevent seizures induced by quinolinic acid in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin attenuates mitochondrial toxin-induced striatal degeneration, with decreasing iNOS/c-Jun levels and activating ERK/Akt pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in phosphorylation of Akt and its downstream signaling targets and suppression of apoptosis by simvastatin after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

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Differential expression of active, phosphorylation-dependent MAP kinases, MAPK/ERK, SAPK/JNK and p38, and specific transcription factor substrates following quinolinic acid excitotoxicity in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid reduces the antioxidant defenses in cerebral cortex of young rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kynurenines in the CNS: from endogenous obscurity to therapeutic importance

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-beta1-42 in the rat hippocampus in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

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Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induced by glutamate in glucose-deprived rat hippocampal slices is prevented by GMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of atorvastatin 10 mg every other day in hypercholesterolemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

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Pravastatin induces rat aortic endothelial cell proliferation and migration via activation of PI3K/Akt/mTOR/p70 S6 kinase signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

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Pharmacology and regional variations of quinolinic acid-evoked excitations in the rat central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

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Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term protective effect of atorvastatin in permanent focal cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PI3K/Akt pathway mediates the neuroprotective effect of atorvastatin in extending thrombolytic therapy after embolic stroke in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of oxidative events in the hippocampus following intracerebroventricular infusion of quinolinic acid in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin reduces the association of NMDA receptors to lipid rafts: a cholesterol-mediated effect in neuroprotection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Simvastatin promotes heat shock protein 27 expression and Akt activation in the rat retina and protects axotomized retinal ganglion cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simplification of the protein assay method of Lowry et al. which is more generally applicable

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropharmacology of quinolinic and kynurenic acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of simvastatin on neuroprotection and modulation of Bcl-2 and BAX in the rat quinolinic acid model of Huntington's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective properties of statins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate-induced toxicity in hippocampal slices involves apoptotic features and p38 MAPK signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphoinositide 3-kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and monoamine transporters: new visions of form and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin reduces neurological deficit and increases synaptogenesis, angiogenesis, and neuronal survival in rats subjected to traumatic brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPases, statins, and nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroprotective effects of atorvastatin against glutamate-induced excitotoxicity in primary cortical neurones

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/19526287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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