Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. (Q45995000)

18 December 2017

title

Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors. (English)

1 reference

18 December 2017

0 references

7

1 reference

18 December 2017

Henri Xhaard

4

object named as

Henri Xhaard

1 reference

18 December 2017

author name string

Anna Minkkilä

1

1 reference

18 December 2017

Juha R Savinainen

2

1 reference

18 December 2017

Heikki Käsnänen

3

1 reference

18 December 2017

Tapio Nevalainen

5

1 reference

18 December 2017

Jarmo T Laitinen

6

1 reference

18 December 2017

Jukka Leppänen

8

1 reference

18 December 2017

Susanna M Saario

9

1 reference

18 December 2017

publication date

1 August 2009

1 reference

18 December 2017

published in

ChemMedChem

1 reference

18 December 2017

volume

4

1 reference

18 December 2017

issue

8

1 reference

18 December 2017

page(s)

1253-1259

1 reference

18 December 2017

Isolation and structure of a brain constituent that binds to the cannabinoid receptor

cites work

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Molecular characterization of a peripheral receptor for cannabinoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Targeting the endocannabinoid system: to enhance or reduce?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Molecular characterization of human and mouse fatty acid amide hydrolases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Brain monoglyceride lipase participating in endocannabinoid inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Modulation of anxiety through blockade of anandamide hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Arachidonylsulfonyl derivatives as cannabinoid CB1 receptor and fatty acid amide hydrolase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Design, synthesis, and in vitro evaluation of carbamate derivatives of 2-benzoxazolyl- and 2-benzothiazolyl-(3-hydroxyphenyl)-methanones as novel fatty acid amide hydrolase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Pharmacological profile of the selective FAAH inhibitor KDS-4103 (URB597).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Monoglyceride lipase as an enzyme hydrolyzing 2-arachidonoylglycerol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

The medicinal chemistry of agents targeting monoacylglycerol lipase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Monoglyceride lipase-like enzymatic activity is responsible for hydrolysis of 2-arachidonoylglycerol in rat cerebellar membranes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Hormone-sensitive lipase: control of intracellular tri-(di-)acylglycerol and cholesteryl ester hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Molecular mechanisms regulating hormone-sensitive lipase and lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Use of an inhibitor to identify members of the hormone-sensitive lipase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Specific inhibition of hormone-sensitive lipase improves lipid profile while reducing plasma glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Carbazates as potent inhibitors of hormone-sensitive lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Pyrrolopyrazinedione-based inhibitors of human hormone-sensitive lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Structure-activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

A fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Studies on new acidic azoles as glucose-lowering agents in obese, diabetic db/db mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Aromatic-aromatic interaction: a mechanism of protein structure stabilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Structure-guided inhibitor design for human FAAH by interspecies active site conversion

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

7 January 2021

inferred from DOI database lookup

Novel Inhibitors of Brain, Neuronal, and Basophilic Anandamide Amidohydrolase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

7 January 2021

inferred from DOI database lookup

Novel inhibitors of fatty acid amide hydrolase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200900137

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1002/CMDC.200900137

1 reference

18 December 2017

release_jmag6ksg6rf6dkcedwqkchizsm

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/jmag6ksg6rf6dkcedwqkchizsm

24 November 2022

mapped directly with Wikidata item

1 reference

18 December 2017