Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities. (Q46007653)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9204916%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9204916%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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F M Donovan

1

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4 November 2019

C J Pike

series ordinal

2

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4 November 2019

C W Cotman

series ordinal

3

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4 November 2019

D D Cunningham

series ordinal

4

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4 November 2019

language of work or name

English

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publication date

1 July 1997

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4 November 2019

published in

Journal of Neuroscience

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4 November 2019

volume

17

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4 November 2019

issue

14

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4 November 2019

page(s)

5316-5326

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Thrombin and its inhibitors regulate morphological and biochemical differentiation of astrocytes in vitro

4 November 2019

cites work

1 reference

12 December 2020

Reciprocal Modulation of Astrocyte Stellation by Thrombin and Protease Nexin-1

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12 December 2020

A small GTP-binding protein, Rho, associates with the platelet-derived growth factor type-beta receptor upon ligand binding.

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Tumorigenic activity of rho genes from Aplysia californica

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Induction of apoptosis by rho in NIH 3T3 cells requires two complementary signals. Ceramides function as a progression factor for apoptosis

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Monocyte chemotaxis: stimulation by specific exosite region in thrombin

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A potential role for apoptosis in neurodegeneration and Alzheimer's disease

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Immunohistochemical evidence for apoptosis in Alzheimer's disease.

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A simple and rapid method for detection of apoptosis in human cells

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Rho family members: activators of MAP kinase cascades.

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Thrombin-elicited contractile responses of aortic smooth muscle

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

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12 December 2020

Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury

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12 December 2020

Thrombin and factor Xa enhance the production of interleukin-1

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12 December 2020

The Rho's progress: a potential role during neuritogenesis for the Rho family of GTPases

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12 December 2020

Clostridium botulinum type C produces a novel ADP-ribosyltransferase distinct from botulinum C2 toxin.

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12 December 2020

Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase

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12 December 2020

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

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12 December 2020

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

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12 December 2020

Cytochalasins Protect Hippocampal Neurons Against Amyloid β‐Peptide Toxicity: Evidence that Actin Depolymerization Suppresses Ca2+ Influx

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12 December 2020

Thrombin-induced redistribution of protein-tyrosine-phosphatases to the cytoskeletal complexes in human platelets

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12 December 2020

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

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12 December 2020

Cellular consequences of thrombin-receptor activation

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12 December 2020

Apoptotic DNA fragmentation in the rat cerebral cortex induced by permanent middle cerebral artery occlusion

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12 December 2020

Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation

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12 December 2020

Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

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12 December 2020

A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes

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12 December 2020

Evidence that actin depolymerization protects hippocampal neurons against excitotoxicity by stabilizing [Ca2+]i

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12 December 2020

G protein-coupled receptors and signaling pathways regulating growth responses.

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12 December 2020

Ligand cross-reactivity within the protease-activated receptor family.

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12 December 2020

Thrombin modulates and reverses neuroblastoma neurite outgrowth

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12 December 2020

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

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12 December 2020

Protease nexin-1, a potent thrombin inhibitor, is reduced around cerebral blood vessels in Alzheimer's disease

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12 December 2020

Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase.

1 reference

12 December 2020

Endothelin-induced cytoskeletal actin re-organization in cultured astrocytes: inhibition by C3 ADP-ribosyltransferase

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12 December 2020

Neural thrombin and protease nexin I kinetics after murine peripheral nerve injury

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12 December 2020

Thrombin attenuates neuronal cell death and modulates astrocyte reactivity induced by beta-amyloid in vitro

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12 December 2020

Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho.

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12 December 2020

Evidence for apoptotic cell death in Alzheimer's disease.

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12 December 2020

Decreases in protease nexins in Alzheimer's disease brain

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12 December 2020

Prostaglandin E receptor EP3 subtype induces neurite retraction via small GTPase Rho.

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12 December 2020

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

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12 December 2020

Dual effects of thrombin and a 14-amino acid peptide agonist of the thrombin receptor on septal cholinergic neurons.

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12 December 2020

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12 December 2020

Induction of apoptosis in NIH3T3 cells after serum deprivation by overexpression of rho-p21, a GTPase protein of the ras superfamily.

1 reference

12 December 2020

Enhancement of the synthesis and secretion of nerve growth factor in primary cultures of glial cells by proteases: a possible involvement of thrombin.

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12 December 2020

DNA damage and repair in central nervous system injury: National Institute of Neurological Disorders and Stroke Workshop Summary.

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12 December 2020

Regulation of platelet-derived growth factor ligand and receptor gene expression by alpha-thrombin in vascular smooth muscle cells

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12 December 2020

Differential phenotypic expression induced in cultured rat astroblasts by acidic fibroblast growth factor, epidermal growth factor, and thrombin

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12 December 2020

Thrombin accumulation in brains of patients with Alzheimer's disease

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12 December 2020

Role of specific cell surface receptors in thrombin-stimulated cell division

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12 December 2020

Differential regulation of protein-tyrosine phosphatases by integrin alpha IIb beta 3 through cytoskeletal reorganization and tyrosine phosphorylation in human platelets

1 reference

12 December 2020

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

12 December 2020

Thrombin may contribute to the pathophysiology of central nervous system injury

1 reference

12 December 2020

Growth of a rat neuroblastoma cell line in serum-free supplemented medium

1 reference

12 December 2020

Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor

1 reference

12 December 2020

cDNA cloning and expression of a hamster alpha-thrombin receptor coupled to Ca2+ mobilization

1 reference

12 December 2020

Synergistic Activation of Rat Brain Phospholipase D by ADP-ribosylation Factor and rhoA p21, and Its Inhibition by Clostridium botulinum C3 Exoenzyme

1 reference

12 December 2020

An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

1 reference

12 December 2020

Thrombin is a regulator of astrocytic endothelin-1.

1 reference

12 December 2020

rho gene products, botulinum C3 exoenzyme and cell adhesion

1 reference

12 December 2020

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

1 reference

12 December 2020

Pathological proteins in senile plaques.

1 reference

12 December 2020

Thrombin is a potent mitogen for rat astroblasts but not for oligodendroblasts and neuroblasts in primary culture

1 reference

12 December 2020

Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells

1 reference

12 December 2020

Modulation of morphological differentiation of human neuroepithelial cells by serine proteases: independence from blood coagulation

1 reference

12 December 2020

Differential translocation of phospholipase C isozymes to integrin-mediated cytoskeletal complexes in thrombin-stimulated human platelets

1 reference

12 December 2020

Protease nexin-1, an antithrombin with neurite outgrowth activity, is reduced in Alzheimer disease

1 reference

12 December 2020

Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho

1 reference

12 December 2020

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

1 reference

12 December 2020

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

1 reference

12 December 2020

ADP-ribosylation of the rhoA gene product by botulinum C3 exoenzyme causes Swiss 3T3 cells to accumulate in the G1 phase of the cell cycle.

1 reference

12 December 2020

10.1523/JNEUROSCI.17-14-05316.1997

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9204916%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9204916%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

9204916

1 reference