The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. (Q46014500)

18 December 2017

title

The Src-like adaptor protein downregulates the T cell receptor on CD4+CD8+ thymocytes and regulates positive selection. (English)

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18 December 2017

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Sosinowski T

1

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18 December 2017

Killeen N

series ordinal

2

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18 December 2017

Weiss A

series ordinal

3

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18 December 2017

language of work or name

English

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publication date

1 September 2001

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18 December 2017

published in

Immunity

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18 December 2017

volume

15

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18 December 2017

issue

3

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18 December 2017

page(s)

457-466

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18 December 2017

Positive selection of thymocytes: the long and winding road.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Evidence for a differential avidity model of T cell selection in the thymus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

A differential-avidity model for T-cell selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Activation events during thymic selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Positive selection as a developmental progression initiated by alpha beta TCR signals that fix TCR specificity prior to lineage commitment.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

T-cell-specific deletion of T-cell receptor transgenes allows functional rearrangement of endogenous α- and β-genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Exclusion and inclusion of α and β T cell receptor alleles

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Activation-induced ubiquitination of the T cell antigen receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

ZAP-70 deficiency in an autosomal recessive form of severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Quantitation of the cell surface level of Ld resulting in positive versus negative selection of the 2C transgenic T cell receptor in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Precommitment of CD4+CD8+ thymocytes to either CD4 or CD8 lineages

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Differences in the level of expression of class I major histocompatibility complex proteins on thymic epithelial and dendritic cells influence the decision of immature thymocytes between positive and negative selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine proteinase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Positive and Negative CD4+ Thymocyte Selection by a Single MHC Class II/Peptide Ligand Affected by Its Expression Level in the Thymus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Restoration of thymocyte development and function in zap-70-/- mice by the Syk protein tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Mice lacking MHC class II molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

T cell receptor antagonist peptides induce positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Negative selection in the thymus includes semimature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

On the dynamics of TCR:CD3 complex cell surface expression and downmodulation

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Inverse correlation between steady‐state RNA and cell surface T cell receptor levels

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

The effect of thymus environment on T cell development and tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

How many thymocytes audition for selection?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Profound block in thymocyte development in mice lacking p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Gene targeting in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Src-like adaptor protein (Slap) is a negative regulator of mitogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Mature T cell reactivity altered by peptide agonist that induces positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Selection of the T cell repertoire.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Positive and negative thymocyte selection induced by different concentrations of a single peptide

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Role of TCR zeta chain in T cell development and selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Src-like adaptor protein (SLAP) is a negative regulator of T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

CD69 expression during selection and maturation of CD4+8+ thymocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Lymphocyte populations and immune responses in CD5-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Development of mature CD8+ thymocytes: selection rather than instruction?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

T cell activation determined by T cell receptor number and tunable thresholds.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

The agonist-antagonist balance in positive selection.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

Analysis of immature (CD4-CD8-) thymic subsets in T-cell receptor alpha beta transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selection

1 reference

https://api.crossref.org/works/10.1016%2FS1074-7613%2801%2900195-9

7 January 2021

10.1016/S1074-7613(01)00195-9

Identifiers

DOI

1 reference

18 December 2017

PubMed ID

11567635

1 reference

18 December 2017