PAR1 cleavage and signaling in response to activated protein C and thrombin. (Q46022355)

18 December 2017

title

PAR1 cleavage and signaling in response to activated protein C and thrombin. (English)

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18 December 2017

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Matthew J Ludeman

1

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18 December 2017

Hiroshi Kataoka

2

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18 December 2017

Yoga Srinivasan

3

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18 December 2017

Naomi L Esmon

4

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18 December 2017

Charles T Esmon

5

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18 December 2017

Shaun R Coughlin

6

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18 December 2017

language of work or name

English

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publication date

21 January 2005

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18 December 2017

Journal of Biological Chemistry

number of pages

7

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based on heuristic

inferred from page(s)

published in

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18 December 2017

volume

280

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18 December 2017

issue

13

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18 December 2017

page(s)

13122-13128

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18 December 2017

cites work

The Protein C Pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410381200

Thrombin signalling and protease-activated receptors

21 January 2018

1 reference

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Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410381200

Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

21 January 2018

1 reference

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Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells

21 January 2018

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Plasmin induces Cyr61 gene expression in fibroblasts via protease-activated receptor-1 and p44/42 mitogen-activated protein kinase-dependent signaling pathway

21 January 2018

1 reference

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The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.

21 January 2018

1 reference

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Efficacy and safety of recombinant human activated protein C for severe sepsis

21 January 2018

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

21 January 2018

1 reference

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Specificity of coagulation factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410381200

Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion

21 January 2018

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Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

21 January 2018

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Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB.

21 January 2018

1 reference

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Stimulation of Endothelial Cell Prostacyclin Production by Thrombin, Trypsin, and the Ionophore A 23187

21 January 2018

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21 January 2018

Protein C activation.

1 reference

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Regulated shedding of PAR1 N-terminal exodomain from endothelial cells

21 January 2018

1 reference

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What is all that thrombin for?

21 January 2018

1 reference

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Pharmacokinetic-pharmacodynamic analysis of drotrecogin alfa (activated) in patients with severe sepsis

21 January 2018

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Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

21 January 2018

1 reference

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Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

21 January 2018

1 reference

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Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo.

21 January 2018

1 reference

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Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

21 January 2018

1 reference

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Cleavage of the thrombin receptor: identification of potential activators and inactivators

21 January 2018

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An assay for high-sensitivity detection of thrombin activity and determination of proteases activating or inactivating protease-activated receptors.

21 January 2018

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Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway

21 January 2018

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Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

21 January 2018

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The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia

21 January 2018

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Role of tissue factor and protease-activated receptors in a mouse model of endotoxemia.

21 January 2018

1 reference

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Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon

21 January 2018

1 reference

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Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein-C-deficient mice.

21 January 2018

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Activated protein C in sepsis

21 January 2018

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The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18

21 January 2018

1 reference

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Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

21 January 2018

1 reference

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Protein C pathway in sepsis

21 January 2018

1 reference

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Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410381200

21 January 2018

Identifiers

DOI

10.1074/JBC.M410381200

1 reference

18 December 2017

PubMed ID

15665002

1 reference

18 December 2017