Copy number polymorphisms are not a common feature of innate immune genes (Q46096624)

19 December 2017

title

Copy number polymorphisms are not a common feature of innate immune genes (English)

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19 December 2017

author

Tomas Ganz

series ordinal

2

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19 December 2017

author name string

Rose M Linzmeier

series ordinal

1

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19 December 2017

publication date

17 April 2006

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19 December 2017

published in

Genomics

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19 December 2017

volume

88

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19 December 2017

issue

1

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19 December 2017

page(s)

122-126

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19 December 2017

Segmental duplications: organization and impact within the current human genome project assembly

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Copy-number polymorphisms: mining the tip of an iceberg

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Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster

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Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3

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Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in alpha- and beta-defensin regions at 8p22-p23.

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Segmental duplications and the evolution of the primate genome

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Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan

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Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme

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Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family

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Evolution of duplications in the transferrin family of proteins

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Cathelicidins, multifunctional peptides of the innate immunity

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The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved

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Meet the relatives: a family of BPI- and LBP-related proteins

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Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter

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The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression

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Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells.

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Antimicrobial polypeptides

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Innate immune defence in the human gastrointestinal tract.

7 January 2021

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How neutrophils kill microbes

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Lactoferrin and host defence: an overview of its immuno-modulating and anti-inflammatory properties

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The antimicrobial activity of lactoferrin: current status and perspectives

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The human cathelicidin LL-37: a multifunctional peptide involved in infection and inflammation in the lung

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New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of β-defensins, LL37, and TLR2

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Vitamin D induces the antimicrobial protein hCAP18 in human skin

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Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3

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7 January 2021

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7 January 2021

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Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G

7 January 2021

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The proximal promoter of the human cathepsin G gene conferring myeloid-specific expression includes C/EBP, c-myb and PU.1 binding sites

7 January 2021

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AML-1, PU.1, and Sp3 regulate expression of human bactericidal/permeability-increasing protein

7 January 2021

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Lipid mediator-induced expression of bactericidal/ permeability-increasing protein (BPI) in human mucosal epithelia

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7 January 2021

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Innate defenses of the intestinal epithelial barrier

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Neutrophil elastase: path clearer, pathogen killer, or just pathologic?

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Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense

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7 January 2021

Identifiers

DOI

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19 December 2017

PubMed ID

16617005

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19 December 2017