Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. (Q46157232)

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21 December 2019

title

Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog (English)

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21 December 2019

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3

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21 December 2019

author name string

Guo-Dong Li

1

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21 December 2019

David C Chiara

2

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21 December 2019

S Shaukat Husain

4

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21 December 2019

Richard W Olsen

5

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21 December 2019

Jonathan B Cohen

6

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21 December 2019

language of work or name

English

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publication date

1 November 2006

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21 December 2019

published in

Journal of Neuroscience

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21 December 2019

volume

26

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21 December 2019

issue

45

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21 December 2019

page(s)

11599-11605

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Fast prediction and visualization of protein binding pockets with PASS.

21 December 2019

cites work

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12 December 2020

Nicotinic receptors at the amino acid level

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12 December 2020

Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic.

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12 December 2020

Specific binding sites for alcohols and anesthetics on ligand-gated ion channels

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12 December 2020

Anesthetics and ion channels: molecular models and sites of action

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12 December 2020

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

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12 December 2020

Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors.

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12 December 2020

Enhanced neurosteroid potentiation of ternary GABA(A) receptors containing the delta subunit.

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12 December 2020

Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations

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12 December 2020

Anxiety over GABA(A) receptor structure relieved by AChBP.

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12 December 2020

Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.

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12 December 2020

General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.

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12 December 2020

2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels

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12 December 2020

Structure and gating mechanism of the acetylcholine receptor pore

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12 December 2020

Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.

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12 December 2020

Defining the propofol binding site location on the GABAA receptor

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12 December 2020

Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic

1 reference

12 December 2020

Gating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation

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12 December 2020

Identification of a general anesthetic binding site in the diacylglycerol-binding domain of protein kinase Cdelta

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12 December 2020

Fishing for allosteric sites on GABA(A) receptors

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12 December 2020

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

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12 December 2020

Comparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function.

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12 December 2020

Emerging molecular mechanisms of general anesthetic action.

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12 December 2020

Dynamic structural investigations on the torpedo nicotinic acetylcholine receptor by time-resolved photoaffinity labeling

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12 December 2020

Recent advances in Cys-loop receptor structure and function

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12 December 2020

State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.

1 reference

12 December 2020

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

1 reference

12 December 2020

Convulsant/barbiturate activity on the soluble gamma-aminobutyric acid-benzodiazepine receptor complex

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12 December 2020

The gamma-aminobutyric-acid/benzodiazepine-receptor protein from rat brain. Large-scale purification and preparation of antibodies

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12 December 2020

Solubilization by CHAPS detergent of barbiturate-enhanced benzodiazepine-GABA receptor complex

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12 December 2020

A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex

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12 December 2020

A gamma-aminobutyric acid/benzodiazepine receptor complex from bovine cerebral cortex. Improved purification with preservation of regulatory sites and their interactions

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12 December 2020

Use of o-phthalaldehyde to reduce background during automated Edman degradation

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12 December 2020

Molecular and cellular mechanisms of general anaesthesia

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12 December 2020

Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes.

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12 December 2020

Identification of a [3H]muscimol photoaffinity substrate in the bovine gamma-aminobutyric acidA receptor alpha subunit.

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12 December 2020

The major site of photoaffinity labeling of the gamma-aminobutyric acid type A receptor by [3H]flunitrazepam is histidine 102 of the alpha subunit.

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12 December 2020

Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor

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12 December 2020

Distinct loci mediate the direct and indirect actions of the anesthetic etomidate at GABA(A) receptors.

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12 December 2020

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

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12 December 2020

The interaction of the general anesthetic etomidate with the gamma-aminobutyric acid type A receptor is influenced by a single amino acid

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12 December 2020

Characterization of a mouse serotonin 5-HT3 receptor purified from mammalian cells.

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12 December 2020

Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.

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12 December 2020

Stereoselective effects of etomidate optical isomers on gamma-aminobutyric acid type A receptors and animals

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12 December 2020

10.1523/JNEUROSCI.3467-06.2006

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21 December 2019

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