Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans (Q46157547)

20 December 2017

title

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans (English)

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20 December 2017

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7

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Klaus Langohr

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Mitona Pujadas

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Yann Hérault

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Mara Dierssen Sotos

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Arnaud Duchon

Arnaud Duchon

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Maria Martinez de Lagran

María Martínez de Lagran

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Nathalie Janel

Nathalie Janel

14

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María-Isabel Covas

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Maria Isabel Covas

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20 December 2017

Magí Farré

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Magí Farré

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20 December 2017

author name string

Rafael De la Torre

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20 December 2017

Susana De Sola

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20 December 2017

Meritxell Pons

3

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Bessy Benejam

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Joan Rodriguez

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Jean Charles Bizot

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Aída Cuenca

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Silvina Catuara

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Henri Blehaut

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Jean Marie Delabar

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publication date

14 September 2013

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20 December 2017

Molecular Nutrition and Food Research

published in

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20 December 2017

volume

58

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issue

2

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20 December 2017

page(s)

278-288

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20 December 2017

Effects of green tea and EGCG on cardiovascular and metabolic health

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Green tea polyphenols rescue of brain defects induced by overexpression of DYRK1A.

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Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice

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Alterations in the phenotype of neocortical pyramidal cells in the Dyrk1A+/- mouse

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Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.

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DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome.

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Dyrk1A influences neuronal morphogenesis through regulation of cytoskeletal dynamics in mammalian cortical neurons.

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A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

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Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice.

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A mouse model for Down syndrome exhibits learning and behaviour deficits.

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Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

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Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

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Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

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DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase

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Biochemical alterations in patients with Down syndrome

21 January 2018

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Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome.

21 January 2018

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Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MNFR.201300325

1 reference

20 December 2017

PubMed ID

24039182

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20 December 2017