Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. (Q46208530)

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29 December 2019

title

Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice (English)

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29 December 2019

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Vitaly Vasilevko

1

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29 December 2019

Feng Xu

2

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29 December 2019

Mary Lou Previti

3

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29 December 2019

William E Van Nostrand

4

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29 December 2019

David H Cribbs

5

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29 December 2019

language of work or name

English

0 references

publication date

1 December 2007

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29 December 2019

published in

Journal of Neuroscience

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29 December 2019

volume

27

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29 December 2019

issue

49

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29 December 2019

page(s)

13376-13383

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High affinity binding of monoclonal antibodies to the sequential epitope EFRH of beta-amyloid peptide is essential for modulation of fibrillar aggregation

29 December 2019

cites work

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

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Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillogenesis.

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Adjuvant-dependent modulation of Th1 and Th2 responses to immunization with beta-amyloid

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Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

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Short-term beta-amyloid vaccinations do not improve cognitive performance in cognitively impaired APP + PS1 mice.

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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

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Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease

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Evidence for peripheral clearance of cerebral Abeta protein following chronic, active Abeta immunization in PSAPP mice

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Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor

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Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

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12 December 2020

An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-beta derivatives.

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Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease

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Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome

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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

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12 December 2020

Current progress in beta-amyloid immunotherapy

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Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease

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Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide

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12 December 2020

Age- and region-dependent alterations in Abeta-degrading enzymes: implications for Abeta-induced disorders

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12 December 2020

Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging

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12 December 2020

Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein

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12 December 2020

Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid peptide

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12 December 2020

Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double A beta in human A betaPP transgenic mice

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12 December 2020

Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral

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Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

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IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor.

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A dynamic relationship between intracellular and extracellular pools of Abeta

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Novel approaches for immunotherapeutic intervention in Alzheimer's disease

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Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models

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12 December 2020

Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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Disaggregation of Alzheimer beta-amyloid by site-directed mAb.

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Immunogenicity of filamentous phage displaying peptide mimotopes after oral administration

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12 December 2020

10.1523/JNEUROSCI.2788-07.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18057195%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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29 December 2019

PubMed publication ID

18057195

1 reference