Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity (Q46220244)

20 December 2017

title

Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity (English)

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20 December 2017

author name string

Guadagno TM

series ordinal

1

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20 December 2017

Newport JW

series ordinal

2

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20 December 2017

language of work or name

English

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publication date

1 January 1996

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20 December 2017

published in

Cell

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20 December 2017

volume

84

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20 December 2017

page(s)

73-82

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20 December 2017

issue

1

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20 December 2017

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle.

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Completion of DNA replication is monitored by a feedback system that controls the initiation of mitosis in vitro: studies in Xenopus

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Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF

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Association of human cyclin E with a periodic G1-S phase protein kinase

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The cdc25 protein contains an intrinsic phosphatase activity

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The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

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Fission yeast genes involved in coupling mitosis to completion of DNA replication

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Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

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Fission yeast p107wee1 mitotic inhibitor is a tyrosine/serine kinase

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The MO15 gene encodes the catalytic subunit of a protein kinase that activates cdc2 and other cyclin-dependent kinases (CDKs) through phosphorylation of Thr161 and its homologues

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A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase

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Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

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cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2.

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Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

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Inhibition of cyclin-dependent kinases by p21

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Checkpoints: controls that ensure the order of cell cycle events

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Rules to replicate by

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Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age

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Elimination of cdc2 phosphorylation sites in the cdc25 phosphatase blocks initiation of M-phase

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Periodic changes in phosphorylation of the Xenopus cdc25 phosphatase regulate its activity

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Early events in DNA replication require cyclin E and are blocked by p21CIP1.

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Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

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Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14

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Regulation of the cdc25 protein during the cell cycle in Xenopus extracts

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Control of the Cdc2/cyclin B complex in Xenopus egg extracts arrested at a G2/M checkpoint with DNA synthesis inhibitors

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Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase

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Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis.

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The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle.

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Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

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Cyclin synthesis drives the early embryonic cell cycle

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7 January 2021

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

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Ordering S phase and M phase in the cell cycle

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Cyclin A is required at two points in the human cell cycle

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7 January 2021

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts

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G1 events and regulation of cell proliferation

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7 January 2021

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Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

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Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

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7 January 2021

The B-type cyclin kinase inhibitor p40SIC1 controls the G1 to S transition in S. cerevisiae

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7 January 2021

G1 phase progression: cycling on cue

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7 January 2021

Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2.

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7 January 2021

Cyclin activation of p34cdc2.

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7 January 2021

Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

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7 January 2021

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

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7 January 2021

Distinct roles for cyclin-dependent kinases in cell cycle control

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7 January 2021

An analysis of the regulation of DNA synthesis by cdk2, Cip1, and licensing factor

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7 January 2021

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Identifiers

DOI

1 reference

20 December 2017

PubMed ID

8548828

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20 December 2017