Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study (Q46223071)

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scientific article published on 20 May 2013

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English	Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study	scientific article published on 20 May 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study (English)

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

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1 reference

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author name string

Pillaiyar Thanigaimalai

1

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Sho Konno

2

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Takehito Yamamoto

3

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Yuji Koiwai

4

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Akihiro Taguchi

5

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Kentaro Takayama

6

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Fumika Yakushiji

7

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Kenichi Akaji

8

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Yoshiaki Kiso

9

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Europe PubMed Central

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20 December 2017

http://europepmc.org/abstract/MED/23747811

Yuko Kawasaki

10

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Europe PubMed Central

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20 December 2017

http://europepmc.org/abstract/MED/23747811

Shen-En Chen

11

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Aurash Naser-Tavakolian

12

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Arne Schön

13

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Ernesto Freire

14

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Yoshio Hayashi

15

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20 December 2017

http://europepmc.org/abstract/MED/23747811

publication date

20 May 2013

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

European Journal of Medicinal Chemistry

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Europe PubMed Central

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20 December 2017

http://europepmc.org/abstract/MED/23747811

65

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

436-447

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Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro

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https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human coronavirus NL63: a clinically important virus?

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https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

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New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

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Design of wide-spectrum inhibitors targeting coronavirus main proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel coronavirus associated with severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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A major outbreak of severe acute respiratory syndrome in Hong Kong

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms and enzymes involved in SARS coronavirus genome expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-range cooperative interactions modulate dimerization in SARS 3CLpro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The novel human coronaviruses NL63 and HKU1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Genome sequence of the SARS-associated coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

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Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronavirus as a possible cause of severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23747811

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.EJMECH.2013.05.005

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

20 December 2017

http://europepmc.org/abstract/MED/23747811

ResearchGate publication ID

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