Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium. (Q46249834)

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English	Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium.	scientific article

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19005642%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19005642%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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Alejandro Galindo-Tovar

1

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17 January 2020

author name string

Maria Luisa Vargas

2

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17 January 2020

Alberto J Kaumann

3

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17 January 2020

publication date

14 November 2008

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17 January 2020

Naunyn-Schmiedeberg's Archives of Pharmacology

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17 January 2020

379

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17 January 2020

4

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17 January 2020

379-384

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17 January 2020

(-)-CGP 12177-induced increase of human atrial contraction through a putative third beta-adrenoceptor

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0367-7

21 January 2018

Differences between the third cardiac beta-adrenoceptor and the colonic beta 3-adrenoceptor in the rat.

1 reference

https://api.crossref.org/works/10.1007%2FS00210-008-0367-7

21 January 2018

A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the affinity of beta-blockers for two states of the beta 1-adrenoceptor in ferret ventricular myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Putative beta 4-adrenoceptors in rat ventricle mediate increases in contractile force and cell Ca2+: comparison with atrial receptors and relationship to (-)-[3H]-CGP 12177 binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constitutive phosphodiesterase activity restricts spontaneous beating rate of cardiac pacemaker cells by suppressing local Ca2+ releases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The low-affinity site of the beta1-adrenoceptor and its relevance to cardiovascular pharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of cyclic AMP-dependent protein kinase in rat atria by (-)-CGP 12177 through an atypical beta-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Direct activation of cardiac pacemaker channels by intracellular cyclic AMP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+) -stimulated basal adenylyl cyclase activity localization in membrane lipid microdomains of cardiac sinoatrial nodal pacemaker cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through beta(2)-adrenoceptors than the effects of (-)-noradrenaline through beta (1)-adrenoceptors in human atrial myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of cardiac rate by "funny" channels in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of (-)-[3H]-CGP12177 at two sites in recombinant human beta 1-adrenoceptors and interaction with beta-blockers

1 reference

https://pubmed.ncbi.nlm.nih.gov/19005642

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00210-008-0367-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19005642%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19005642%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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