Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels (Q46262337)

http://europepmc.org/abstract/MED/18987181

20 December 2017

title

Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels (English)

1 reference

http://europepmc.org/abstract/MED/18987181

20 December 2017

author name string

David R Riddell

1

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16 May 2020

Hua Zhou

2

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16 May 2020

Kevin Atchison

3

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16 May 2020

Helen K Warwick

4

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16 May 2020

Peter J Atkinson

5

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16 May 2020

Julius Jefferson

6

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16 May 2020

Lin Xu

7

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16 May 2020

Suzan Aschmies

8

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16 May 2020

Yolanda Kirksey

9

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16 May 2020

Yun Hu

10

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16 May 2020

Erik Wagner

11

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16 May 2020

Adrienne Parratt

12

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16 May 2020

Jane Xu

13

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16 May 2020

Zhuting Li

14

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16 May 2020

Margaret M Zaleska

15

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16 May 2020

J Steve Jacobsen

16

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16 May 2020

Menelas N Pangalos

17

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16 May 2020

Peter H Reinhart

18

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16 May 2020

language of work or name

English

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publication date

1 November 2008

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http://europepmc.org/abstract/MED/18987181

20 December 2017

published in

Journal of Neuroscience

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16 May 2020

volume

28

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16 May 2020

issue

45

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16 May 2020

page(s)

11445-11453

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671315&resulttype=core&format=json

Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse.

16 May 2020

cites work

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Apo E structure determines VLDL clearance and atherosclerosis risk in mice.

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12 December 2020

Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent.

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Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage

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Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis.

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Susceptibility of transgenic mice expressing human apolipoprotein E to closed head injury: the allele E3 is neuroprotective whereas E4 increases fatalities.

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion.

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Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis.

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Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

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CNS synaptogenesis promoted by glia-derived cholesterol

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Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease.

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Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

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Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycans.

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Role of cholesterol in synapse formation and function

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APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis

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Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis

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Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.

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Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro

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A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

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ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

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Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

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Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice.

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12 December 2020

Accelerated evolution of brain atrophy and "black holes" in MS patients with APOE-epsilon 4.

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Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux

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12 December 2020

ApoE genotype accounts for the vast majority of AD risk and AD pathology

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12 December 2020

ApoE and Abeta1-42 interactions: effects of isoform and conformation on structure and function

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12 December 2020

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides.

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12 December 2020

Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model

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12 December 2020

The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism

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12 December 2020

Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

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12 December 2020

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

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12 December 2020

Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease

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12 December 2020

ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.

1 reference

12 December 2020

Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

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12 December 2020

The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons.

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12 December 2020

Presence of an APOE4 allele results in significantly earlier onset of Parkinson's disease and a higher risk with dementia.

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12 December 2020

Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide.

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Effect of domain interaction on apolipoprotein E levels in mouse brain.

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12 December 2020

Selective effects of the APOE epsilon4 allele on presynaptic cholinergic markers in the neocortex of Alzheimer's disease

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The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

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Apolipoprotein E structure: insights into function.

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Apolipoprotein E gene polymorphism, total plasma cholesterol level, and Parkinson disease dementia.

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12 December 2020

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

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12 December 2020

Apolipoprotein E genotype does not associate with disease severity measured by Multiple Sclerosis Severity Score

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12 December 2020

Protein folding, unfolding and misfolding: role played by intermediate States

1 reference

12 December 2020

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI

1 reference

12 December 2020

Reciprocal effects of apolipoprotein E alleles (epsilon 2 and epsilon 4) on plasma lipid levels in normolipidemic subjects

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12 December 2020

Abnormal in vivo metabolism of apolipoprotein E4 in humans

1 reference

12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

1 reference

12 December 2020

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

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12 December 2020

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor.

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12 December 2020

Lysosomal degradation and sorting of apolipoprotein E in macrophages.

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Quantitation of apolipoprotein E

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12 December 2020

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.

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Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis.

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12 December 2020

Human apolipoprotein E: the Alzheimer's disease connection.

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12 December 2020

Changes in phenotypes of apolipoprotein E and apolipoprotein(a) in liver transplant recipients

1 reference

12 December 2020

Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia.

1 reference

12 December 2020

Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury.

1 reference

12 December 2020

Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.

1 reference

12 December 2020

Nascent astrocyte particles differ from lipoproteins in CSF.

1 reference

12 December 2020

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

1 reference

12 December 2020

Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury

1 reference

12 December 2020

10.1523/JNEUROSCI.1972-08.2008

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6671315&resulttype=core&format=json

16 May 2020

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16 May 2020

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