Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype (Q46264351)

20 December 2017

title

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype (English)

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20 December 2017

author name string

Xiuying Bai

1

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20 December 2017

Qiu Dinghong

2

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20 December 2017

Dengshun Miao

3

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20 December 2017

David Goltzman

4

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20 December 2017

Andrew C Karaplis

5

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20 December 2017

publication date

4 November 2008

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20 December 2017

American Journal of Physiology - Endocrinology and Metabolism

published in

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20 December 2017

volume

296

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20 December 2017

page(s)

E79-88

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20 December 2017

issue

1

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20 December 2017

Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders

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The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

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The parathyroid is a target organ for FGF23 in rats

21 January 2018

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An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia.

21 January 2018

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A translocation causing increased alpha-klotho level results in hypophosphatemic rickets and hyperparathyroidism

21 January 2018

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Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23

21 January 2018

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Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.

21 January 2018

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A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

21 January 2018

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Cellular and molecular mechanism of low-turnover osteopenia in the klotho-deficient mouse.

21 January 2018

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Fibroblast growth factor-23 regulates parathyroid hormone and 1alpha-hydroxylase expression in cultured bovine parathyroid cells.

21 January 2018

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Regulation of bone mass by Wnt signaling

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

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Endocrine FGFs and Klothos: emerging concepts

21 January 2018

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Augmented Wnt signaling in a mammalian model of accelerated aging

21 January 2018

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Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice

21 January 2018

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Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage

21 January 2018

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Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo

21 January 2018

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Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

21 January 2018

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Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals

21 January 2018

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PHEX, FGF23, DMP1 and beyond

21 January 2018

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Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis

21 January 2018

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

21 January 2018

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Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

21 January 2018

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10.1152/AJPENDO.90539.2008

21 January 2018

Identifiers

DOI

1 reference

20 December 2017

PubMed ID

18984852

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20 December 2017