Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. (Q46327498)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18840432%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18840432%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

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1

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15 January 2020

author name string

Daisuke Uchida

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18840432%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

Norio Ishida

series ordinal

3

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15 January 2020

language of work or name

English

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publication date

7 October 2008

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15 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18840432%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

volume

582

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15 January 2020

issue

25-26

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15 January 2020

page(s)

3639-3642

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Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis

15 January 2020

cites work

1 reference

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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

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FGF21: a missing link in the biology of fasting.

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The fasting polypeptide FGF21 can enter brain from blood

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Bezafibrate, a peroxisome proliferator-activated receptors agonist, decreases body temperature and enhances electroencephalogram delta-oscillation during sleep in mice

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Circadian clocks are resounding in peripheral tissues

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Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids

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CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice.

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PPARalpha is a potential therapeutic target of drugs to treat circadian rhythm sleep disorders.

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The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man.

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Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans

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Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis.

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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states

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PPARalpha is a key regulator of hepatic FGF21.

21 January 2018

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Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

21 January 2018

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Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes

21 January 2018

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Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting

21 January 2018

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