Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. (Q46394678)

PubMed publication ID

17192425

21 December 2017

http://europepmc.org/abstract/MED/17192425

title

Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674728&resulttype=core&format=json

11 May 2020

author name string

Michael J Saganich

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674728&resulttype=core&format=json

11 May 2020

Brock E Schroeder

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674728&resulttype=core&format=json

11 May 2020

Veronica Galvan

3

1 reference

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11 May 2020

Dale E Bredesen

4

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11 May 2020

Edward H Koo

5

1 reference

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11 May 2020

Stephen F Heinemann

6

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11 May 2020

language of work or name

English

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publication date

1 December 2006

1 reference

PubMed publication ID

17192425

21 December 2017

http://europepmc.org/abstract/MED/17192425

published in

Journal of Neuroscience

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11 May 2020

volume

26

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11 May 2020

issue

52

1 reference

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11 May 2020

page(s)

13428-13436

1 reference

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

11 May 2020

cites work

1 reference

12 December 2020

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

1 reference

12 December 2020

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1 reference

12 December 2020

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1 reference

12 December 2020

A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

1 reference

12 December 2020

Apolipoprotein E and cognitive performance

1 reference

12 December 2020

Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.

1 reference

12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

1 reference

12 December 2020

In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice

1 reference

12 December 2020

Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease

1 reference

12 December 2020

The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases

1 reference

12 December 2020

1 reference

12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

12 December 2020

Maintained synaptophysin immunoreactivity in Tg2576 transgenic mice during aging: correlations with cognitive impairment.

1 reference

12 December 2020

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model

1 reference

12 December 2020

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

1 reference

12 December 2020

Caspase cleavage of members of the amyloid precursor family of proteins

1 reference

12 December 2020

Reversible memory loss in a mouse transgenic model of Alzheimer's disease

1 reference

12 December 2020

Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice

1 reference

12 December 2020

APP processing and synaptic function

1 reference

12 December 2020

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

1 reference

12 December 2020

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

1 reference

12 December 2020

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

12 December 2020

Caspase cleavage of the amyloid precursor protein modulates amyloid β‐protein toxicity

1 reference

12 December 2020

Accumulation of caspase cleaved amyloid precursor protein represents an early neurodegenerative event in aging and in Alzheimer's disease.

1 reference

12 December 2020

Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes

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12 December 2020

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12 December 2020

Deciphering the molecular basis of memory failure in Alzheimer's disease

1 reference

12 December 2020

Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

12 December 2020

Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo

1 reference

12 December 2020

Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy

1 reference

12 December 2020

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

1 reference

12 December 2020

Activity-dependent recruitment of silent synapses.

1 reference

12 December 2020

Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624)

1 reference

12 December 2020

Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

1 reference

12 December 2020

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

12 December 2020

Evidence for silent synapses: Implications for the expression of LTP

1 reference

12 December 2020

Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system.

1 reference

12 December 2020

Long-term potentiation in cultures of single hippocampal granule cells: a presynaptic form of plasticity

1 reference

12 December 2020

10.1523/JNEUROSCI.4180-06.2006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674728&resulttype=core&format=json

11 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6674728&resulttype=core&format=json

11 May 2020

PubMed publication ID

17192425

1 reference