Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes (Q46396936)

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scientific article published on 18 July 2008

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English	Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes	scientific article published on 18 July 2008

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18641273

Metformin normalizes endothelial function by suppressing vasoconstrictor prostanoids in mesenteric arteries from OLETF rats, a model of type 2 diabetes (English)

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Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18641273

type 2 diabetes

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Takayuki Matsumoto

1

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Europe PubMed Central

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21 December 2017

http://europepmc.org/abstract/MED/18641273

Eri Noguchi

2

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Europe PubMed Central

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21 December 2017

http://europepmc.org/abstract/MED/18641273

Keiko Ishida

3

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Europe PubMed Central

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21 December 2017

http://europepmc.org/abstract/MED/18641273

Tsuneo Kobayashi

4

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21 December 2017

http://europepmc.org/abstract/MED/18641273

Nobuhiro Yamada

5

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21 December 2017

http://europepmc.org/abstract/MED/18641273

Katsuo Kamata

6

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21 December 2017

http://europepmc.org/abstract/MED/18641273

publication date

18 July 2008

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Europe PubMed Central

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21 December 2017

http://europepmc.org/abstract/MED/18641273

American Journal of Physiology Heart and Circulatory Physiology

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21 December 2017

http://europepmc.org/abstract/MED/18641273

295

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21 December 2017

http://europepmc.org/abstract/MED/18641273

3

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Europe PubMed Central

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21 December 2017

http://europepmc.org/abstract/MED/18641273

H1165-H1176

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18641273

Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Oxidative damage, plasma antioxidant capacity, and glucemic control in elderly NIDDM patients

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric oxide synthase and consequent S-nitrosylation of cyclooxygenase-2.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Cyclooxygenase involvement in thromboxane-dependent contraction in rat mesenteric resistance arteries

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Endothelial dysfunction in diabetes.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

EDHF: new therapeutic targets?

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Metformin prevents glucose-induced protein kinase C-beta2 activation in human umbilical vein endothelial cells through an antioxidant mechanism

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Effect of thiazolidinediones and metformin on LDL oxidation and aortic endothelium relaxation in diabetic GK rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Metformin improves vascular function in insulin-resistant rats.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Metformin: An Update

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Improved endothelial function with metformin in type 2 diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Cilostazol improves endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats.

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Enhanced vascular reactivity of small mesenteric arteries from diabetic mice is associated with enhanced oxidative stress and cyclooxygenase products

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Calcium and reactive oxygen species increase in endothelial cells in response to releasers of endothelium-derived contracting factor

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Altered Expression of Small-Conductance Ca2+-Activated K+ (SK3) Channels Modulates Arterial Tone and Blood Pressure

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

1 reference

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Anti-diabetic biguanides inhibit hormone-induced intracellular Ca2+ concentration oscillations in rat hepatocytes

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Endothelium-dependent contractions in hypertension

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.00486.2008

21 January 2018

Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium

1 reference

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21 January 2018

Focus on prostacyclin and its novel mimetics

1 reference

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Cation transport activity of anion exchanger 1 mutations found in inherited distal renal tubular acidosis.

1 reference

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21 January 2018

Global and societal implications of the diabetes epidemic

1 reference

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Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

1 reference

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21 January 2018

Identifiers

10.1152/AJPHEART.00486.2008

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18641273

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

21 December 2017

http://europepmc.org/abstract/MED/18641273

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