Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity (Q46408478)

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scientific article published on 28 August 2008

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English	Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity	scientific article published on 28 August 2008

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scholarly article

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

Blockade of NMDA receptors in the prefrontal cortex increases dopamine and acetylcholine release in the nucleus accumbens and motor activity (English)

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

nucleus accumbens

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Gregorio Segovia

2

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

author name string

Alberto Del Arco

1

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

Francisco Mora

3

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21 December 2017

http://europepmc.org/abstract/MED/18751970

publication date

28 August 2008

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21 December 2017

http://europepmc.org/abstract/MED/18751970

Psychopharmacology

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21 December 2017

http://europepmc.org/abstract/MED/18751970

201

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

3

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

325-338

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Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

https://scigraph.springernature.com/pub.10.1007/s00213-008-1288-3

0 references

Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers

1 reference

https://api.crossref.org/works/10.1007%2FS00213-008-1288-3

21 January 2018

Putting a spin on the dorsal-ventral divide of the striatum.

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https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor hypofunction produces concomitant firing rate potentiation and burst activity reduction in the prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraaccumbal mecamylamine infusion does not affect dopamine output in the nucleus accumbens of chronically nicotine-treated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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Opposite effects of prefrontal cortex and nucleus accumbens infusions of flupenthixol on stimulant-induced locomotion and brain stimulation reward

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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Unique behavioral effects of the NMDA antagonist, CPP, upon injection into the medial pre-frontal cortex of rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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A comparison of the effects of neuroleptics on phencyclidine-induced behaviors in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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Cortical regulation of acetylcholine release in rat striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

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Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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The nitric oxide system modulates the in vivo release of acetylcholine in the nucleus accumbens induced by stimulation of the hippocampal fornix/fimbria-projection

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The behavioral effects of MK-801 injected into nucleus accumbens and caudate-putamen of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

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Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of exploratory locomotor activity and increase in dopamine turnover following the local application of cis-flupenthixol into limbic projection areas of the rat striatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical stimulation of the prefrontal cortex increases cholecystokinin, glutamate, and dopamine release in the nucleus accumbens: an in vivo microdialysis study in freely moving rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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Stress, prefrontal cortex and environmental enrichment: studies on dopamine and acetylcholine release and working memory performance in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

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NMDA receptor hypofunction produces opposite effects on prefrontal cortex interneurons and pyramidal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

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Role of high-affinity choline uptake on extracellular choline and acetylcholine evoked by NMDA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

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Laterodorsal tegmental projections to identified cell populations in the rat ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of nucleus accumbens dopamine in the neurochemical and behavioral effects of phencyclidine: a microdialysis and behavioral study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frontal-striatal cognitive deficits in patients with chronic schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: Comparisons to other psychomotor stimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dysfunctional brain dopamine systems induced by psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contrasting mechanisms of action and sensitivity to antipsychotics of phencyclidine versus amphetamine: importance of nucleus accumbens 5-HT2Asites for PCP-induced locomotion in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate receptor-dependent modulation of dopamine efflux in the nucleus accumbens by basolateral, but not central, nucleus of the amygdala in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of psychostimulant-induced locomotor activity in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Injection of the competitive NMDA receptor antagonist AP-5 into the nucleus accumbens of monoamine-depleted mice induces pronounced locomotor stimulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Input from the frontal cortex and the parafascicular nucleus to cholinergic interneurons in the dorsal striatum of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of medial prefrontal cortex by phencyclidine is mediated via a hippocampo-prefrontal pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phencyclidine interferes with the hippocampal gating of nucleus accumbens neuronal activity in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine-independent locomotion following blockade of N-methyl-D-aspartate receptors in the ventral tegmental area.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microinjections of a nicotinic agonist into dopamine terminal fields: effects on locomotion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polyamines inhibit N-methyl-D-aspartate antagonist-induced darting behavior in the rat prefrontal cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ketamine, at a dose that disrupts motor behavior and latent inhibition, enhances prefrontal cortex synaptic efficacy and glutamate release in the nucleus accumbens

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Do non-dopaminergic neurons in the ventral tegmental area play a role in the responses elicited in A10 dopaminergic neurons by electrical stimulation of the prefrontal cortex?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prefrontal cortex lesions cause only minor effects on the hyperlocomotion induced by MK-801 and its reversal by clozapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant actions of d-amphetamine and apomorphine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serotonin model of schizophrenia: emerging role of glutamate mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prefrontal cortical involvement in phencyclidine-induced activation of the mesolimbic dopamine system: behavioral and neurochemical evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Excessive cerebrocortical release of acetylcholine induced by NMDA antagonists is reduced by GABAergic and alpha2-adrenergic agonists.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute administration of phencyclidine induces tonic activation of medial prefrontal cortex neurons in freely moving rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of endogenous glutamate on extracellular concentrations of GABA, dopamine, and dopamine metabolites in the prefrontal cortex of the freely moving rat: involvement of NMDA and AMPA/KA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of aging on the interaction between glutamate, dopamine, and GABA in striatum and nucleus accumbens of the awake rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cerebral cortex and parafascicular thalamic nucleus facilitate in vivo acetylcholine release in the rat striatum through distinct glutamate receptor subtypes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Projections from the rat prefrontal cortex to the ventral tegmental area: target specificity in the synaptic associations with mesoaccumbens and mesocortical neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor antagonists decrease GABA outflow from the septum and increase acetylcholine outflow from the hippocampus: a microdialysis study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antipsychotic drugs reverse the disruption in prefrontal cortex function produced by NMDA receptor blockade with phencyclidine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dizocilpine (MK-801) elicits a tetrodotoxin-sensitive increase in extracellular release of dopamine in rat medial frontal cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical regulation of subcortical dopamine release: mediation via the ventral tegmental area

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Glutamate Neurotransmission in the Prefrontal Cortex Sustains the Motoric and Dopaminergic Effects of Phencyclidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of ketamine in normal and schizophrenic volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperactivity to novelty induced by social isolation is not correlated with changes in D2 receptor function and binding in striatum

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of 4-aminopyridine on extracellular concentrations of glutamate in striatum of the freely moving rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hippocampal and midline thalamic fibers and terminals in relation to the choline acetyltransferase-immunoreactive neurons in nucleus accumbens of the rat: a light and electron microscopic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of phencyclidine with drugs affecting cholinergic neurotransmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous glutamate increases extracellular concentrations of dopamine, GABA, and taurine through NMDA and AMPA/kainate receptors in striatum of the freely moving rat: a microdialysis study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting prefrontal cortical dopamine D1 and N-methyl-D-aspartate receptor interactions in schizophrenia treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and behavioral pharmacology of the mesocortical dopamine system

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A proposed hypothalamic-thalamic-striatal axis for the integration of energy balance, arousal, and food reward

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate and schizophrenia: beyond the dopamine hypothesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive NMDA receptor antagonists do not produce locomotor hyperactivity by a dopamine-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of acute and repeated systemic administration of ketamine on prefrontal acetylcholine release and sustained attention performance in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nucleus accumbens acetylcholine regulates appetitive learning and motivation for food via activation of muscarinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of cholinergic stimulation in the nucleus accumbens on locomotor behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiologically based treatment interventions in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18751970

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-008-1288-3

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

1 reference

Europe PubMed Central

21 December 2017

http://europepmc.org/abstract/MED/18751970

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