Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules (Q46419582)

22 December 2017

review article

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title

Protein kinase C: a paradigm for regulation of protein function by two membrane-targeting modules (English)

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22 December 2017

author name string

A C Newton

series ordinal

1

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22 December 2017

J E Johnson

series ordinal

2

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22 December 2017

publication date

1 August 1998

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22 December 2017

Biochimica et Biophysica Acta

published in

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22 December 2017

volume

1376

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22 December 2017

issue

2

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22 December 2017

page(s)

155-172

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22 December 2017

Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation

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Protein kinase C and phospholipase C: bilayer interactions and regulation

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Mechanism of interaction of protein kinase C with phorbol esters. Reversibility and nature of membrane association

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In vitro activation and substrates of recombinant, baculovirus expressed human protein kinase C mu

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Taxonomy and function of C1 protein kinase C homology domains

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Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

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Identification and characterization of zinc binding sites in protein kinase C.

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Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

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Solution structure of a cysteine rich domain of rat protein kinase C.

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NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions

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Stoichiometric binding of diacylglycerol to the phorbol ester receptor

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7 January 2021

Calcium-independent binding to interfacial phorbol esters causes protein kinase C to associate with membranes in the absence of acidic lipids

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7 January 2021

Cysteine-rich regions of protein kinase Cdelta are functionally non-equivalent. Differences between cysteine-rich regions of non-calcium-dependent protein kinase Cdelta and calcium-dependent protein kinase Cgamma

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7 January 2021

Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells

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7 January 2021

Protein kinase Calpha contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities.

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Phospholipid and Ca++ dependency of phorbol ester receptors

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Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties

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Ca(2+)-independent protein kinase Cs contain an amino-terminal domain similar to the C2 consensus sequence

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Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin

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The C2 domain calcium-binding motif: structural and functional diversity

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Regulation of protein kinase C betaII by its C2 domain

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Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

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7 January 2021

Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C

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C2 domain conformational changes in phospholipase C-delta 1

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A ternary metal binding site in the C2 domain of phosphoinositide-specific phospholipase C-delta1

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Ca2+-signaling cycle of a membrane-docking C2 domain

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A putative phosphatidylserine binding motif is not involved in the lipid regulation of protein kinase C.

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Protein kinase C interaction with calcium: a phospholipid-dependent process

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Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes

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Independent folding and ligand specificity of the C2 calcium-dependent lipid binding domain of cytosolic phospholipase A2

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7 January 2021

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain

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7 January 2021

Peptides that mimic the pseudosubstrate region of protein kinase C bind to acidic lipids in membranes

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7 January 2021

Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses

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7 January 2021

Determination of the specific substrate sequence motifs of protein kinase C isozymes

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7 January 2021

Localization of protein kinases by anchoring proteins: a theme in signal transduction

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7 January 2021

Protein kinase C isozymes and substrates

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7 January 2021

Protein kinase C: ports of anchor in the cell

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7 January 2021

Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C

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7 January 2021

Ca2+ differentially regulates conventional protein kinase Cs' membrane interaction and activation

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7 January 2021

Protein kinase C is regulated in vivo by three functionally distinct phosphorylations

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7 January 2021

Determination of in Vivo Phosphorylation Sites in Protein Kinase C

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7 January 2021

Activation of the epidermal growth factor receptor signal transduction pathway stimulates tyrosine phosphorylation of protein kinase C delta

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7 January 2021

Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.

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7 January 2021

Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation

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Phosphoinositide-specific phospholipase C-delta 1 binds with high affinity to phospholipid vesicles containing phosphatidylinositol 4,5-bisphosphate

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7 January 2021

Mechanism of activation of protein kinase C: roles of diolein and phosphatidylserine

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7 January 2021

Interaction of protein kinase C with phosphatidylserine. 1. Cooperativity in lipid binding

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7 January 2021

Association of protein kinase C with phospholipid vesicles

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7 January 2021

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

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7 January 2021

A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters

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7 January 2021

Association of protein kinase C with phospholipid monolayers: two-stage irreversible binding

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7 January 2021

The role of protein kinase C in cell surface signal transduction and tumour promotion

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7 January 2021

Chemical specificity and physical properties of the lipid bilayer in the regulation of protein kinase C by anionic phospholipids: evidence for the lack of a specific binding site for phosphatidylserine

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7 January 2021

Extensive segregation of acidic phospholipids in membranes induced by protein kinase C and related proteins

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7 January 2021

Membrane domains containing phosphatidylserine and substrate can be important for the activation of protein kinase C.

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7 January 2021

Supplementation of the phosphatidyl-L-serine requirement of protein kinase C with nonactivating phospholipids

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7 January 2021

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications

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7 January 2021

Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol

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7 January 2021

Phosphatidylcholine-dependent protein kinase C activation. Effects of cis-fatty acid and diacylglycerol on synergism, autophosphorylation and Ca2+-dependency

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7 January 2021

Quantitation of the interaction of protein kinase C with diacylglycerol and phosphoinositides by time-resolved detection of resonance energy transfer

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7 January 2021

Mechanism of protein kinase C activation by phosphatidylinositol 4,5-bisphosphate

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7 January 2021

Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes

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7 January 2021

The role of membrane biophysical properties in the regulation of protein kinase C activity

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7 January 2021

Role of cofactors in protein kinase C activation

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7 January 2021

The effects of non-lamellar forming lipids on membrane protein-lipid interactions

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7 January 2021

Effect of phospholipid unsaturation on protein kinase C activation

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7 January 2021

Role of membrane defects in the regulation of the activity of protein kinase C.

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7 January 2021

Lipid lateral heterogeneity in phosphatidylcholine/phosphatidylserine/diacylglycerol vesicles and its influence on protein kinase C activation

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7 January 2021

Activation of protein kinase C by coexisting diacylglycerol-enriched and diacylglycerol-poor lipid domains

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7 January 2021

Inhibition of protein kinase C by alcohols and anaesthetics

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7 January 2021

10.1016/S0304-4157(98)00003-3

Identifiers

DOI

1 reference

22 December 2017

1 reference

22 December 2017