Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol. (Q46419852)

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English	Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.	scientific article

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12 January 2020

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol (English)

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Volker Eulenburg

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Volker Eulenburg

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Heinrich Betz

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Mireille Lerner-Natoli

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Mireille Lerner-Natoli

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Chuan-Sheng Zhang

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Federica Bertaso

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Greta Ann Herin

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Liane Bauer

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Joel Bockaert

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Laurent Fagni

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Astrid Scheschonka

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1 August 2008

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12 January 2020

Journal of Neuroscience

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8604-8614

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12 January 2020

(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Long-term depression in hippocampal interneurons: joint requirement for pre- and postsynaptic events.

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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PICK1 interacts with and regulates PKC phosphorylation of mGLUR7

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons

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12 December 2020

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Interaction of the C-terminal tail region of the metabotropic glutamate receptor 7 with the protein kinase C substrate PICK1.

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site.

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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PDZ domains: structural modules for protein complex assembly

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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The inhibition of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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G-protein-coupled receptors for neurotransmitter amino acids: C-terminal tails, crowded signalosomes

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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PICK1 is required for the control of synaptic transmission by the metabotropic glutamate receptor 7

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Different binding motifs in metabotropic glutamate receptor type 7b for filamin A, protein phosphatase 1C, protein interacting with protein kinase C (PICK) 1 and syntenin allow the formation of multimeric protein complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Reduction of excitatory postsynaptic responses by persistently active metabotropic glutamate receptors in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Making protein interactions druggable: targeting PDZ domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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mGluR7 is a metaplastic switch controlling bidirectional plasticity of feedforward inhibition.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Pias1 interaction and sumoylation of metabotropic glutamate receptor 8

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12 December 2020

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Agonists and antagonists for group III metabotropic glutamate receptors 6, 7 and 8.

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https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels: implications for stress-related psychiatric disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Altered seizure susceptibility in mice lacking the Ca(v)2.3 E-type Ca2+ channel.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Sumoylation in neurons: nuclear and synaptic roles?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Effects of excitatory amino acid antagonists on evoked and spontaneous excitatory potentials in guinea-pig hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Modulation by zinc ions of native rat and recombinant human inhibitory glycine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal LTP in the range of the theta frequency.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Glycinergic synapses in the rod pathway of the rat retina: cone bipolar cells express the alpha 1 subunit of the glycine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Regional and developmental profile of modulation of hippocampal synaptic transmission and LTP by AP4-sensitive mGluRs in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Target-cell-specific concentration of a metabotropic glutamate receptor in the presynaptic active zone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Pharmacological antagonism of the actions of group II and III mGluR agonists in the lateral perforant path of rat hippocampal slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Compartmental localization of a metabotropic glutamate receptor (mGluR7): two different active sites at a retinal synapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

based on heuristic

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Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18716219

12 December 2020

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Identifiers

10.1523/JNEUROSCI.0628-08.2008

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12 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18716219%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18716219%20AND%20SRC:MED&resulttype=core&format=json

12 January 2020

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