Overcoming hurdles in developing successful drugs targeting chemokine receptors (Q46441158)

22 December 2017

review article

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title

Overcoming hurdles in developing successful drugs targeting chemokine receptors (English)

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22 December 2017

author name string

Thomas J Schall

series ordinal

1

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22 December 2017

Amanda E I Proudfoot

series ordinal

2

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22 December 2017

publication date

15 April 2011

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22 December 2017

Nature Reviews Immunology

published in

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22 December 2017

volume

11

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22 December 2017

page(s)

355-363

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22 December 2017

issue

5

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22 December 2017

The chemokine and chemokine receptor superfamilies and their molecular evolution

cites work

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Chemokines and leukocyte traffic

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The many roles of chemokines and chemokine receptors in inflammation

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Inflammation and cancer: back to Virchow?

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Blood monocytes consist of two principal subsets with distinct migratory properties

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Migratory fate and differentiation of blood monocyte subsets

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CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity

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Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice

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Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis.

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Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites

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Understanding selective trafficking of lymphocyte subsets

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Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity

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Demonstration of TARC and CCR4 mRNA expression and distribution using in situ RT-PCR in the lesional skin of atopic dermatitis

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Chemokines and cell migration in secondary lymphoid organs

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Polymorphism in the fractalkine receptor CX3CR1 as a genetic risk factor for coronary artery disease

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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci

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Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritis

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Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells.

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Proteolytic activation of alternative CCR1 ligands in inflammation

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CCR5 blockade in rheumatoid arthritis: a randomised, double-blind, placebo-controlled clinical trial.

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Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

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Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor

21 January 2018

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Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor

21 January 2018

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Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis

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Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis

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CCR1 antagonists: what have we learned from clinical trials

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Anti-chemokine small molecule drugs: a promising future?

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CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis.

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CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions

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Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease

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Determining the potency and molecular mechanism of action of insurmountable antagonists

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IL-8 as Antibody Therapeutic Target in Inflammatory Diseases: Reduction of Clinical Activity in Palmoplantar Pustulosis

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Role of the cytoplasmic tails of CXCR1 and CXCR2 in mediating leukocyte migration, activation, and regulation

31 March 2020

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Intraallograft chemokine RNA and protein during rejection of MHC-matched/multiple minor histocompatibility-disparate skin grafts

31 March 2020

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CCR9 and inflammatory bowel disease

31 March 2020

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Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotrexate in patients with active rheumatoid arthritis. Findings in a prospective, randomized, double-blind, parallel-design clinical trial in thirt

31 March 2020

1 reference

MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept study

31 March 2020

1 reference

Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

International union of pharmacology. XXII. Nomenclature for chemokine receptors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21494268

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI2972

1 reference

22 December 2017

PubMed ID

21494268

1 reference

22 December 2017