Genotoxic effect of bile acids on human normal and tumour colon cells and protection by dietary antioxidants and butyrate. (Q46441488)

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11 January 2020

title

Genotoxic effect of bile acids on human normal and tumour colon cells and protection by dietary antioxidants and butyrate (English)

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11 January 2020

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2

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11 January 2020

author name string

Patrizia Rosignoli

1

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11 January 2020

Angelo De Bartolomeo

3

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11 January 2020

Raffaela Fuccelli

4

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11 January 2020

Maria Antonietta Pelli

5

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11 January 2020

Guido Morozzi

6

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publication date

6 August 2008

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European Journal of Nutrition

11 January 2020

published in

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volume

47

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issue

6

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page(s)

301-309

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Genotoxic activity in human faecal water and the role of bile acids: a study using the alkaline comet assay

11 January 2020

cites work

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12 December 2020

In vitro formation of DNA adducts with bile acids

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12 December 2020

Secondary bile acid induced DNA damage in HT29 cells: are free radicals involved?

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12 December 2020

Short-chain fatty acid in the human colon. Relation to inflammatory bowel diseases and colon cancer.

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12 December 2020

Deoxycholate induces DNA damage and apoptosis in human colon epithelial cells expressing either mutant or wild-type p53.

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12 December 2020

Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics

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12 December 2020

Protective activity of butyrate on hydrogen peroxide-induced DNA damage in isolated human colonocytes and HT29 tumour cells

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12 December 2020

Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids

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12 December 2020

Apoptotic signaling during initiation of detachment-induced apoptosis ("anoikis") of primary human intestinal epithelial cells

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12 December 2020

Genetic stability: the key to longevity?

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12 December 2020

Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA.

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12 December 2020

Acid and bile salts induce DNA damage in human oesophageal cell lines

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12 December 2020

Induction of DNA damage by risk factors of colon cancer in human colon cells derived from biopsies

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12 December 2020

Bile acids, but not neutral sterols, are tumor promoters in the colon in man and in rodents

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12 December 2020

Evaluation of fecal mutagenicity and colorectal cancer risk

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12 December 2020

A simple technique for quantitation of low levels of DNA damage in individual cells

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12 December 2020

Effects on cell proliferation, activator protein-1 and genotoxicity by fecal water from patients with colorectal adenomas

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12 December 2020

Nicotine increases oxidative stress, activates NF-kappaB and GRP78, induces apoptosis and sensitizes cells to genotoxic/xenobiotic stresses by a multiple stress inducer, deoxycholate: relevance to colon carcinogenesis

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12 December 2020

Effects of deoxycholic acid and butyrate on mucosal prostaglandin E2 release and cell proliferation in the human sigmoid colon.

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12 December 2020

Nutritional factors and colon cancer

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12 December 2020

Promoting effect of bile acids on colon carcinogenesis after intrarectal instillation of N-methyl-N'-nitro-N-nitrosoguanidine in rats.

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12 December 2020

Bile acids reduce the apoptosis-inducing effects of sodium butyrate on human colon adenoma (AA/C1) cells: implications for colon carcinogenesis

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12 December 2020

Butyrate modulates DNA-damage-induced p53 response by induction of p53-independent differentiation and apoptosis

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12 December 2020

Bile acid induced gene expression in LT97 colonic adenoma cells

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12 December 2020

Does butyrate protect from colorectal cancer?

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12 December 2020

Analysis of DNA strand breaks, oxidized bases, and glutathione S-transferase P1 in human colon cells from biopsies.

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12 December 2020

Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature

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12 December 2020

The stress-response proteins poly(ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis

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12 December 2020

Bile acids, non-phorbol-ester-type tumor promoters, stimulate the phosphorylation of protein kinase C substrates in human platelets and colon cell line HT29

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12 December 2020

Dihydroxy bile acids activate the transcription of cyclooxygenase-2

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12 December 2020

Butyrate inhibits deoxycholate-induced increase in colonic mucosal DNA and protein synthesis in vivo

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12 December 2020

Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway

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12 December 2020

Deoxycholate induces mitochondrial oxidative stress and activates NF-kappaB through multiple mechanisms in HCT-116 colon epithelial cells

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12 December 2020

Deoxycholic acid causes DNA damage in colonic cells with subsequent induction of caspases, COX-2 promoter activity and the transcription factors NF-kB and AP-1.

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12 December 2020

Effect of colonic luminal components on induction of apoptosis in human colonic cell lines

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12 December 2020

Arachidonic and docosahexaenoic acids reduce the growth of A549 human lung-tumor cells increasing lipid peroxidation and PPARs

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12 December 2020

Colonic health: fermentation and short chain fatty acids

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12 December 2020

Promoting Effect of Sodium Deoxycholate on Colon Adenocarcinomas in Germfree Rats2

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12 December 2020

The contribution of cytotoxicity to DNA-effects in the single cell gel test (comet assay).

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12 December 2020

Activation of the promoters of genes associated with DNA damage, oxidative stress, ER stress and protein malfolding by the bile salt, deoxycholate

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12 December 2020

Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosis.

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12 December 2020

Increased GADD gene expression in human colon epithelial cells exposed to deoxycholate

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12 December 2020

Acute and chronic effect of dietary cholic acid on colonic epithelial cell proliferation

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12 December 2020

Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses.

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12 December 2020

Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation

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12 December 2020

In vivo crypt surface hyperproliferation is decreased by butyrate and increased by deoxycholate in normal rat colon: associated in vivo effects on c-Fos and c-Jun expression

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12 December 2020

Bile acids as carcinogens in human gastrointestinal cancers

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12 December 2020

10.1007/S00394-008-0725-8

Identifiers

DOI

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11 January 2020

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