Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs (Q46447901)

9 June 2018

title

Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs (English)

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9 June 2018

20

Craig W Lindsley

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9 June 2018

Colleen M. Niswender

13

Colleen M Niswender

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9 June 2018

P. Jeffrey Conn

18

P Jeffrey Conn

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9 June 2018

Hyekyung P Cho

10

Hyekyung P Cho

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9 June 2018

Michael Bubser

11

Michael Bubser

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9 June 2018

Darren W. Engers

15

Darren W Engers

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9 June 2018

Meredith J Noetzel

2

Meredith J Noetzel

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9 June 2018

Atin Lamsal

6

Atin Lamsal

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9 June 2018

Bruce J. Melancon

4

Bruce J Melancon

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9 June 2018

Michael S Poslusney

3

Michael S Poslusney

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Nicholas J Brandon

16

Nicholas J Brandon

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9 June 2018

Sichen Chang

7

Sichen Chang

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9 June 2018

Vincent B. Luscombe

8

Vincent B Luscombe

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9 June 2018

Rebecca L Weiner

9

Rebecca L Weiner

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9 June 2018

Carrie K Jones

12

Carrie K Jones

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9 June 2018

author name string

Michael R Wood

1

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James C Tarr

5

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Michael W Wood

14

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Mark E Duggan

17

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Thomas M Bridges

19

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9 June 2018

language of work or name

English

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publication date

30 November 2016

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9 June 2018

Bioorganic & Medicinal Chemistry Letters

number of pages

5

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based on heuristic

inferred from page(s)

published in

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9 June 2018

volume

27

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9 June 2018

issue

2

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9 June 2018

page(s)

171-175

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9 June 2018

Antipsychotic-like Effects of M4 Positive Allosteric Modulators Are Mediated by CB2 Receptor-Dependent Inhibition of Dopamine Release

cites work

1 reference

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Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition

10 June 2018

1 reference

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Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core

10 June 2018

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M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia

10 June 2018

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Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

10 June 2018

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Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

10 June 2018

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Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents

10 June 2018

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Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors

10 June 2018

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Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100

10 June 2018

1 reference

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Discovery of a selective M₄ positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia

10 June 2018

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Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor

10 June 2018

1 reference

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Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

10 June 2018

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Allosteric antipsychotics: m4 muscarinic potentiators as novel treatments for schizophrenia

10 June 2018

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Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties

10 June 2018

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Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

10 June 2018

1 reference

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Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

10 June 2018

1 reference

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Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

10 June 2018

1 reference

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An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

10 June 2018

1 reference

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10.1016/J.BMCL.2016.11.086

10 June 2018

Identifiers

DOI

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9 June 2018

PMC publication ID

5340297

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9 June 2018

PubMed publication ID

27939174

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9 June 2018