Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells (Q46458096)

22 December 2017

title

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells (English)

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22 December 2017

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Xin Mao

1

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22 December 2017

Chun Rong Yu

series ordinal

2

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22 December 2017

Wen Hua Li

series ordinal

3

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22 December 2017

Wen Xin Li

series ordinal

4

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22 December 2017

publication date

1 August 2008

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22 December 2017

published in

Cell Research

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22 December 2017

volume

18

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22 December 2017

issue

8

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22 December 2017

page(s)

879-888

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22 December 2017

Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo

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Anti-inflammatory activity of shikonin derivatives from Arnebia hispidissima

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Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.

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Antitumor activity of shikonin and its derivatives

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Direct reaction between shikonin and thiols induces apoptosis in HL60 cells

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Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells

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Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin

21 January 2018

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Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells

21 January 2018

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p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells

21 January 2018

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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Inhibition of the Bcr-Abl tyrosine kinase as a therapeutic strategy for CML.

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

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Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia

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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

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Death receptors: signaling and modulation

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The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

21 January 2018

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Biochemical pathways of caspase activation during apoptosis

21 January 2018

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Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

21 January 2018

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

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BCL-2 family members and the mitochondria in apoptosis

21 January 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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MCL1 provides a window on the role of the BCL2 family in cell proliferation, differentiation and tumorigenesis

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Cellular response to oxidative stress: signaling for suicide and survival

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Mitochondrial oxidative stress plays a key role in aging and apoptosis

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ROS stress in cancer cells and therapeutic implications

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Regulatory roles of JNK in programmed cell death

21 January 2018

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

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JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery

21 January 2018

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JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

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Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

21 January 2018

1 reference

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Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway

21 January 2018

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Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

21 January 2018

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Antitumor activity of shikonin, alkannin and their derivatives. II. X-ray analysis of cyclo-alkannin leucoacetate, tautomerism of alkannin and cyclo-alkannin and antitumor activity of alkannin derivatives

21 January 2018

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7 January 2021

beta-hydroxyisovalerylshikonin inhibits the cell growth of various cancer cell lines and induces apoptosis in leukemia HL-60 cells through a mechanism different from those of Fas and etoposide

1 reference

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7 January 2021

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

1 reference

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7 January 2021

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.86

7 January 2021

Identifiers

DOI

10.1038/CR.2008.86

1 reference

22 December 2017

release_rvm2top7fjd7lej3g5eypushxu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/rvm2top7fjd7lej3g5eypushxu

24 November 2022

mapped directly with Wikidata item

1 reference

22 December 2017