Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers (Q46504849)

22 December 2017

title

Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers (English)

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22 December 2017

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5

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22 December 2017

author name string

Eric Lévesque

1

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22 December 2017

Marie-Odile Benoit-Biancamano

2

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22 December 2017

Robert Delage

3

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22 December 2017

Félix Couture

4

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22 December 2017

publication date

1 July 2008

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22 December 2017

published in

Pharmacogenomics

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22 December 2017

volume

9

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22 December 2017

issue

7

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22 December 2017

page(s)

869-879

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22 December 2017

Mycophenolates in transplantation

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Highly variable mycophenolate mofetil bioavailability following nonmyeloablative hematopoietic cell transplantation

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Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism.

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The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

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Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats

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The acyl glucuronide metabolite of mycophenolic acid inhibits the proliferation of human mononuclear leukocytes

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Influence of nonsynonymous polymorphisms of UGT1A8 and UGT2B7 metabolizing enzymes on the formation of phenolic and acyl glucuronides of mycophenolic acid

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A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination

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A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

21 January 2018

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Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter protein

21 January 2018

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Pharmacodynamics of mycophenolate mofetil after nonmyeloablative conditioning and unrelated donor hematopoietic cell transplantation

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Identification of common polymorphisms in the promoter of the UGT1A9 gene: evidence that UGT1A9 protein and activity levels are strongly genetically controlled in the liver.

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Clinical pharmacokinetics of mycophenolate mofetil

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Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients.

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Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene

21 January 2018

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Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3.

21 January 2018

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A novel polymorphism in the promoter region of human UGT1A9 gene (UGT1A9*22) and its effects on the transcriptional activity

21 January 2018

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Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/14622416.9.7.869

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22 December 2017

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22 December 2017