Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. (Q46539003)

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3 November 2019

title

Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus (English)

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3 November 2019

author name string

E Bednarski

series ordinal

1

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3 November 2019

C E Ribak

series ordinal

2

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3 November 2019

G Lynch

series ordinal

3

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3 November 2019

language of work or name

English

0 references

publication date

1 June 1997

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3 November 2019

published in

Journal of Neuroscience

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3 November 2019

volume

17

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3 November 2019

page(s)

4006-4021

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3 November 2019

issue

11

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Cytosolic proteolysis of tau by cathepsin D in hippocampus following suppression of cathepsins B and L.

3 November 2019

cites work

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12 December 2020

Participation of cathepsin L on bone resorption

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12 December 2020

Neuronal aging in cultures; An electron-microscopic study

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Fine structure of meganeurites and secondary growth processes in feline GM1-gangliosidosis

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Inhibitors of lysosomal enzymes: accumulation of lipofuscin-like dense bodies in the brain

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Quantitative synaptic alterations in the human neocortex during normal aging

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Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease

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Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Ultrastructural observations on neuronal lipofuscin (age pigment) and dense bodies induced by a proteinase inhibitor, leupeptin, in rat hippocampus.

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Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease

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Cathepsin B, Cathepsin H, and cathepsin L

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The amount and distribution of pigments in neurons and glia of the cerebral cortex. Autofluorescent and ultrastructural studies.

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

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Structural modifications associated with synaptic development in area CA1 of rat hippocampal organotypic cultures.

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Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau.

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The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes

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12 December 2020

beta-Amyloid precursor protein fragments and lysosomal dense bodies are found in rat brain neurons after ventricular infusion of leupeptin.

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A simple method for organotypic cultures of nervous tissue

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Pigmentoarchitectonic pathology of the isocortex in juvenile neuronal ceroid-lipofuscinosis: Axonal enlargements in layer IIIab and cell loss in layer V

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Protease inhibition causes some manifestations of aging and Alzheimer's disease in rodent and primate brain

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Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases

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12 December 2020

Proteases and proteolysis in the lysosome

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12 December 2020

Studies on the mechanisms of autophagy: maturation of the autophagic vacuole

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Induction of beta-amyloid-containing polypeptides in hippocampus: evidence for a concomitant loss of synaptic proteins and interactions with an excitotoxin

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ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA

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12 December 2020

Routes of excretion of neuronal lysosomal dense bodies after ventricular infusion of leupeptin in the rat: a study using ubiquitin and PGP 9.5 immunocytochemistry

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12 December 2020

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

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12 December 2020

The selective role of cathepsins B and D in the lysosomal degradation of endogenous and exogenous proteins

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12 December 2020

A time-lapse video image intensification analysis of cytoplasmic organelle movements during endosome translocation

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12 December 2020

Lipofuscin-like substances accumulate rapidly in brain, retina and internal organs with cysteine protease inhibition

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12 December 2020

Cathepsin L--a lysosomal cysteine proteinase

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12 December 2020

Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: evidence for early up-regulation of the endosomal-lysosomal system.

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12 December 2020

Functions of lysosomes

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12 December 2020

Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain.

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12 December 2020

Translational suppression of calpain blocks long-term potentiation

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12 December 2020

Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease.

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12 December 2020

Increase in cathepsin D activity in rat brain in aging

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12 December 2020

Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies.

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12 December 2020

Intraventricular infusion of leupeptin decreases Bmax of the D2 receptor in the striatum of young rats

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12 December 2020

Aging in the rat olfactory bulb: Quantitative changes in mitral cell organelles and somato-dendritic synapses

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12 December 2020

Time course of synaptic development in hippocampal organotypic cultures.

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12 December 2020

Dendritic transport. II. Somatofugal movement of neuronal lysosomes induced by colchicine: evidence for a novel transport system in dendrites.

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12 December 2020

Induction of calpain-mediated spectrin fragments by pathogenic treatments in long-term hippocampal slices.

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12 December 2020

Cytoskeletal changes in rat cortical neurons induced by long-term intraventricular infusion of leupeptin.

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12 December 2020

Lysosome instability in aged rat brain

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12 December 2020

A protein factor essential for microtubule assembly

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12 December 2020

Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices.

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12 December 2020

Inhibition of proteolysis protects hippocampal neurons from ischemia

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12 December 2020

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

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12 December 2020

Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?

1 reference

12 December 2020

The effects of aging on area 46 of the frontal cortex of the rhesus monkey.

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12 December 2020

Specific assay method for the activities of cathepsin L-type cysteine proteinases

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12 December 2020

Spindle-shaped appendages of IIIab-pyramids filled with lipofuscin: A striking pathological change of the senescent human isocortex

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12 December 2020

INTRACELLULAR LOCALIZATION OF LIPOFUSCIN AGE PIGMENTS IN THE NERVOUS SYSTEM

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12 December 2020

Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases

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12 December 2020

Lipoprotein pigments--their relationship to ageing in the human nervous system. I. The lipofuscin content of nerve cells

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12 December 2020

Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain

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12 December 2020

10.1523/JNEUROSCI.17-11-04006.1997

Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9151717%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9151717%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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