Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia (Q46544733)

23 December 2017

title

Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia (English)

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23 December 2017

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4

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Erwin F. Wagner

11

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Astrid Hoebertz

3

Astrid Hoebertz

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23 December 2017

Harald Scheuch

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Harald Scheuch

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23 December 2017

Michael Amling

10

Michael Amling

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23 December 2017

Latifa Bakiri

2

Latifa Bakiri

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23 December 2017

Vukoslav Komnenovic

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Vukoslav Komnenovic

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23 December 2017

Aline Bozec

1

Aline Bozec

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23 December 2017

author name string

Arndt F Schilling

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Matthias Priemel

8

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23 December 2017

Colin L Stewart

9

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language of work or name

English

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publication date

11 June 2008

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23 December 2017

published in

Nature

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23 December 2017

volume

454

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23 December 2017

page(s)

221-225

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23 December 2017

issue

7201

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23 December 2017

https://scigraph.springernature.com/pub.10.1038/nature07019

exact match

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cites work

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c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

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The AP1 transcription factor Fra2 is required for efficient cartilage development.

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Simultaneous generation offra-2 conditional andfra-2 knock-out mice

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Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

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Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice

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VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia

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Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells

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Hypoxia is a major stimulator of osteoclast formation and bone resorption.

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Hepatocyte growth factor can substitute for M-CSF to support osteoclastogenesis

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Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts.

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The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia signalling

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Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2

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Hypoxia and HIF-1alpha in chondrogenesis

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Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway.

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Fluorescence-based staining for tartrate-resistant acidic phosphatase (TRAP) in osteoclasts combined with other fluorescent dyes and protocols.

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7 January 2021

Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation

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Identifiers

DOI

10.1038/NATURE07019

1 reference

23 December 2017

Dimensions Publication ID

0 references

1 reference

23 December 2017