Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers. (Q46571142)

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scientific article published in September 2005

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English	Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers.	scientific article published in September 2005

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scholarly article

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13 January 2020

Does modafinil activate the locus coeruleus in man? Comparison of modafinil and clonidine on arousal and autonomic functions in human volunteers (English)

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13 January 2020

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13 January 2020

author name string

C Freeman

2

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13 January 2020

R W Langley

3

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13 January 2020

E Szabadi

4

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13 January 2020

C M Bradshaw

5

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13 January 2020

publication date

1 September 2005

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13 January 2020

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13

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Psychopharmacology

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13 January 2020

181

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13 January 2020

3

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13 January 2020

537-549

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13 January 2020

https://scigraph.springernature.com/pub.10.1007/s00213-005-0013-8

0 references

Evidence that locus coeruleus is the site where clonidine and drugs acting at alpha 1- and alpha 2-adrenoceptors affect sleep and arousal mechanisms

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

Modafinil reduces excessive somnolence and enhances mood in patients with myotonic dystrophy

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

Effects of clonidine and yohimbine on the pupillary light reflex and carbachol-evoked sweating in healthy volunteers

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

The neurobiology of sleep: genetics, cellular physiology and subcortical networks

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

Modafinil as adjunct therapy for daytime sleepiness in obstructive sleep apnea

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

The Fourth Lilly Prize Lecture, University of Aberdeen, September 1980. The clinical pharmacology of clonidine and related central antihypertensive agents

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

Acute behavioral and physiological effects of modafinil in drug abusers

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

Comparison of the effects of ranitidine, cimetidine and thioridazine on psychomotor functions in healthy volunteers

1 reference

https://api.crossref.org/works/10.1007%2FS00213-005-0013-8

21 January 2018

Modafinil binds to the dopamine uptake carrier site with low affinity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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Dopaminergic role in stimulant-induced wakefulness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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Wake-promoting agents with different mechanisms of action: comparison of effects of modafinil and amphetamine on food intake and cardiovascular activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Clinical pharmacokinetic profile of modafinil

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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Adjunct modafinil for the short-term treatment of fatigue and sleepiness in patients with major depressive disorder: a preliminary double-blind, placebo-controlled study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Modafinil: a drug in search of a mechanism.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Comparison of the effects of clonidine and yohimbine on pupillary diameter at different illumination levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Modafinil in the treatment of excessive daytime sleepiness in children

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Randomized trial of modafinil for treating subjective daytime sleepiness in patients with Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Moxonidine: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Hypothalamic arousal regions are activated during modafinil-induced wakefulness.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Modafinil treatment of pramipexole-associated somnolence

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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The influence of the baseline on the size of pharmacological responses: a theoretical model [proceedings]

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. II. Effects on two nights of recovery sleep

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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The action of sedatives on brain stem oculomotor systems in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Effects of modafinil on cognitive and meta-cognitive performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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Mathematical procedures in data recording and processing of pupillary fatigue waves

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Effects of clonidine and diazepam on prepulse inhibition of the acoustic startle response and the N1/P2 auditory evoked potential in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Comparison of the effects of clonidine and yohimbine on spontaneous pupillary fluctuations in healthy human volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized trial of the long-term, continued efficacy and safety of modafinil in narcolepsy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypocretin/orexin, sleep and narcolepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Comparison of the effects of high ambient temperature and clonidine on autonomic functions in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Comparison of the effects of venlafaxine, paroxetine and desipramine on the pupillary light reflex in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive enhancing effects of modafinil in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of a new central adrenergic agonist--modafinil--and D-amphetamine on sleep and early morning behaviour in young healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Where you least expect it: dopamine in the pons and modulation of sleep and REM-sleep

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of clonidine on the fear-inhibited light reflex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hypocretins: setting the arousal threshold

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Relative potencies of alpha-1 and alpha-2 antagonists in the locus ceruleus, dorsal raphe and dorsal lateral geniculate nuclei: an electrophysiological study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Opposite effects of noradrenaline and acetylcholine upon hypocretin/orexin versus melanin concentrating hormone neurons in rat hypothalamic slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Functional magnetic resonance imaging neuroactivation studies in normal subjects and subjects with the narcoleptic syndrome. Actions of modafinil.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Critical flicker frequency (CFF) and psychotropic drugs in normal human subjects?A review

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Changes in autonomic function with age: a study of pupillary kinetics in healthy young and old people

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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Immunostaining of cholinergic pontomesencephalic neurons for alpha 1 versus alpha 2 adrenergic receptors suggests different sleep-wake state activities and roles

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha 2-adrenergic receptor-mediated presynaptic inhibition of GABAergic IPSPs in rat histaminergic neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imidazoline receptors and their endogenous ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

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Histamine-immunoreactive nerve fibers in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

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The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of clonidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modafinil improves alertness, vigilance, and executive function during simulated night shifts

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modafinil improves recovery after general anesthesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and safety of modafinil (Provigil) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Locus coeruleus control of spinal motor output

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SHP Test—an Aid in the Detection and Measurement of Depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modafinil treatment of opioid-induced sedation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arousal effect of orexin A depends on activation of the histaminergic system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The sleep switch: hypothalamic control of sleep and wakefulness

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal alpha 1- and alpha 2-adrenoceptors mediate facilitation and inhibition of spinal motor transmission, respectively

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A double-blind, placebo-controlled investigation of the efficacy of modafinil for sustaining the alertness and performance of aviators: a helicopter simulator study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modafinil affects mood, but not cognitive function, in healthy young volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The fear-inhibited light reflex: importance of the anticipation of an aversive event.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonidine reduces sympathetic activity but maintains baroreflex responses in normotensive humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modafinil, d-amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Randomized trial of modafinil for the treatment of pathological somnolence in narcolepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Benefits of adjunct modafinil in an open-label, pilot study in patients with schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the wake-promoting agent modafinil on sleep-promoting neurons from the ventrolateral preoptic nucleus: an in vitro pharmacologic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of clonidine and diazepam on the acoustic startle response and on its inhibition by 'prepulses' in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Does short-term treatment with modafinil affect blood pressure in patients with obstructive sleep apnea?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cognitive-enhancing properties of modafinil are limited in non-sleep-deprived middle-aged volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of dexmedetomidine, an alpha2-adrenoceptor agonist, on human pupillary reflexes during general anaesthesia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15983798

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00213-005-0013-8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15983798%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15983798%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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