Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes (Q46593986)

23 December 2017

title

Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes (English)

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23 December 2017

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David I Finkelstein

5

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Ashley I. Bush

object named as

Ashley I Bush

4

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author name string

He Xu

1

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23 December 2017

Victoria M Perreau

2

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23 December 2017

Krista A Dent

3

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23 December 2017

Paul A Adlard

6

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23 December 2017

publication date

10 February 2016

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23 December 2017

Journal of Alzheimer's Disease

published in

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23 December 2017

volume

51

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23 December 2017

issue

2

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23 December 2017

page(s)

471-487

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23 December 2017

Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities

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Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain

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Both targeted mass spectrometry and flow sorting analysis methods detected the decreased serum apolipoprotein E level in Alzheimer's disease patients

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

21 January 2018

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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

21 January 2018

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Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease

21 January 2018

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The generation and function of soluble apoE receptors in the CNS

21 January 2018

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LRP: a multifunctional scavenger and signaling receptor

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Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk

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Genetic interaction between two apolipoprotein E receptors increases Alzheimer's disease risk.

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Association of ApoE and LRP mRNA levels with dementia and AD neuropathology

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Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

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Apoptosis of cultured astrocytes induced by the copper and neocuproine complex through oxidative stress and JNK activation.

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Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways

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Zinc deficiency increases the susceptibility of human neuroblastoma cells to lead-induced activator protein-1 activation

21 January 2018

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Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

21 January 2018

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Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins

21 January 2018

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Profiling the iron, copper and zinc content in primary neuron and astrocyte cultures by rapid online quantitative size exclusion chromatography-inductively coupled plasma-mass spectrometry

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Quantitative susceptibility mapping by inversion of a perturbation field model: correlation with brain iron in normal aging

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Iron levels in the human brain: a post-mortem study of anatomical region differences and age-related changes

21 January 2018

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The metallobiology of Alzheimer's disease

21 January 2018

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Iron quantification in cerebrospinal fluid

21 January 2018

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Iron: a pathological mediator of Alzheimer disease?

21 January 2018

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Ternary complexes of iron, amyloid-beta, and nitrilotriacetic acid: binding affinities, redox properties, and relevance to iron-induced oxidative stress in Alzheimer's disease

21 January 2018

1 reference

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Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

21 January 2018

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Apolipoprotein E and lipid homeostasis in the etiology and treatment of sporadic Alzheimer's disease.

21 January 2018

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The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

21 January 2018

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ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

21 January 2018

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Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

21 January 2018

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Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

21 January 2018

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Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning

21 January 2018

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Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

21 January 2018

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

21 January 2018

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Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain

21 January 2018

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Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytes

21 January 2018

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LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes

21 January 2018

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LRP-1 and LRP-2 receptors function in the membrane neuron. Trafficking mechanisms and proteolytic processing in Alzheimer's disease

21 January 2018

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Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Iron increases APP translation and amyloid-beta production in the retina

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Altered APP Carboxyl-Terminal Processing Under Ferrous Iron Treatment in PC12 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Physiological and pathological aspects of Abeta in iron homeostasis via 5'UTR in the APP mRNA and the therapeutic use of iron-chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150797

21 January 2018

Identifiers

DOI

10.3233/JAD-150797

1 reference

23 December 2017

1 reference

23 December 2017